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E 5531

Known as: E-5531, E5531 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Lipid A
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
The cellular Toll-like receptor 4 antagonist E5531 can act as an agonist in horse whole blood.
Highly Cited
2001
Highly Cited
2001
A Novel Synthetic Acyclic Lipid A-like Agonist Activates Cells via the Lipopolysaccharide/Toll-like Receptor 4 Signaling Pathway*
ER-112022 is a novel acyclic synthetic lipid A analog that contains six symmetrically organized fatty acids on a noncarbohydrate… 
2000
2000
Consequences of Interaction of a Lipophilic Endotoxin Antagonist with Plasma Lipoproteins
ABSTRACT E5531, a novel synthetic lipid A analogue, antagonizes the toxic effects of lipopolysaccharide, making it a potential… 
2000
2000
The Effect of Divalent Cations on the Membrane Properties and Pharmacokinetics in Rat of the Lipid A Analogue E5531
To obtain information on the effects of Ca2+ on the membrane properties of the lipid A analogue E5531, we have determined the… 
Highly Cited
1999
Highly Cited
1999
E5531, a synthetic non‐toxic lipid A derivative blocks the immunobiological activities of lipopolysaccharide
The major pathological responses to Gram‐negative bacterial sepsis are triggered by endotoxin or lipopolysaccharide. As endotoxin… 
1999
1999
Lipoprotein Distribution of a Novel Endotoxin Antagonist, E5531, in Plasma from Human Subjects with Various Lipid Levels
ABSTRACT The purpose of this study was to determine the distribution profile of a novel endotoxin antagonist, [14C]E5531, at 1 μg… 
1999
1999
The effect of the lipid A analog, E5531 on fever induced by endotoxin from Escherichia coli.
E5531 is a specific lipid A antagonist and is expected to be a drug for the treatment of septic shock. The LAL (limulus amebocyte… 
1998
1998
The effect of the lipid A analog E5531 on phospholipid membrane properties
Highly Cited
1995
Highly Cited
1995
E5531, a pure endotoxin antagonist of high potency.
Shock due to Gram-negative bacterial sepsis is a consequence of acute inflammatory response to lipopolysaccharide (LPS) or… 
1995
1995
Anti-endotoxin activity of a novel synthetic lipid A analog.
Lipid As from non-toxic bacteria such as Rhodobacter capsulatus and Rhodobacter sphaeroides have been shown to antagonize the… 
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