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E 3330

Known as: E-3330, E3330 
National Institutes of Health

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2 relations

Broader (2)

BenzoquinonesPropionates

Papers overview

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2016
2016
Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a potentially debilitating side effect of a number of chemotherapeutic… 
Highly Cited
2013
Highly Cited
2013
NADPH Oxidase Limits Lipopolysaccharide-Induced Lung Inflammation and Injury in Mice through Reduction-Oxidation Regulation of NF-κB Activity
Although reactive oxygen species (ROS) produced by NADPH oxidase are known to regulate inflammatory responses, the impact of ROS… 
2013
2013
Specific Inhibition of the Redox Activity of Ape1/Ref-1 by E3330 Blocks Tnf-Α-Induced Activation of Il-8 Production in Liver Cancer Cell Lines
APE1/Ref-1 is a main regulator of cellular response to oxidative stress via DNA-repair function and co-activating activity on the… 
2011
2011
Apurinic/Apyrimidinic endonuclease 1 regulates inflammatory response in macrophages.
The multi-functional apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) DNA repair and redox signaling protein has been… 
Highly Cited
2011
Highly Cited
2011
Impact of APE1/Ref-1 Redox Inhibition on Pancreatic Tumor Growth
Pancreatic cancer is especially a deadly form of cancer with a survival rate less than 2%. Pancreatic cancers respond poorly to… 
2010
2010
Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis.
Highly Cited
2009
Highly Cited
2009
The Ape‐1/Ref‐1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: Therapeutic implications in tumor angiogenesis
The apurinic/apyrimidinic endonuclease 1/redox factor‐1 (Ape‐1/Ref‐1) is a multi‐functional protein, involved in DNA repair and… 
Highly Cited
2008
Highly Cited
2008
Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration
AP endonuclease 1 (APE1; also known as REF-1) contains a DNA repair domain and a redox regulation domain. APE1 is overexpressed… 
Highly Cited
2007
Highly Cited
2007
Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain.
Ape1 is a molecule with dual functions in DNA repair and redox regulation of transcription factors. In Ape1-deficient mice… 
Highly Cited
1998
Highly Cited
1998
Nuclear targeted suppression of NF-kappa B activity by the novel quinone derivative E3330.
The activation of NF-kappa B consists of at least three steps: degradation of I kappa B alpha, translocation of NF-kappa B into… 
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