Dutasteride

Known as: (5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide, 17beta-N-(2,5-bis(trifluoromethyl))phenyl-carbamoyl-4-aza-5alpha-androst-1-en-3-one, Dutasteride [Chemical/Ingredient] 
A synthetic 4-azasteroid compound. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5 alpha-reductase, forming stable enzyme… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
BACKGROUND We aimed to investigate the safety and efficacy of dutasteride, a 5α-reductase inhibitor, on prostate cancer… (More)
Is this relevant?
Highly Cited
2012
Highly Cited
2012
BACKGROUND Findings of studies on the association between androgens and prostate cancer (PCa) are mixed. Androgens may affect… (More)
  • figure 1
  • table 1
  • table 2
  • table 3
  • table 4
Is this relevant?
Highly Cited
2011
Highly Cited
2011
OBJECTIVE • To assess the efficacy and safety of dutasteride compared with finasteride in treating men with symptomatic benign… (More)
  • figure 1
  • figure 2
  • table 1
  • table 2
  • figure 4
Is this relevant?
Highly Cited
2010
Highly Cited
2010
BACKGROUND We conducted a study to determine whether dutasteride reduces the risk of incident prostate cancer, as detected on… (More)
  • table 1
  • figure 1
  • figure 2
  • table 2
  • table 3
Is this relevant?
Highly Cited
2010
Highly Cited
2010
BACKGROUND Combination therapy with dutasteride and tamsulosin provides significantly greater benefit than either monotherapy for… (More)
  • table 1
  • figure 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2008
Highly Cited
2008
PURPOSE We investigated whether combination therapy with dutasteride and tamsulosin is more effective than either monotherapy… (More)
Is this relevant?
2005
2005
Dihydrotestosterone is the main molecule responsible for androgenic alopecia. Finasteride, which reduces transformation of… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
PURPOSE Chemoprevention may significantly impact the natural history of prostate cancer. The most potent intraprostatic androgen… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
OBJECTIVES The Symptom Management After Reducing Therapy (SMART-1) study examined the combination of the dual action 5alpha… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
OBJECTIVES To study the efficacy and safety of dutasteride, a dual inhibitor of the 5-alpha-reductase isoenzymes types I and II… (More)
Is this relevant?