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Drug Evaluation, Preclinical

Known as: Preclinical Drug Evaluations, Evaluation Studies, Drug, Pre-Clinical, Screening, Drug 
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
National Institutes of Health

Related topics

Related topics

4 relations

Broader (1)

Screening procedure
Toxicity Testsnursing therapystandards characteristics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Prodrugs of anthracyclines in cancer chemotherapy.
Designing and developing truly tumor-specific prodrugs remains a challenge in the field of cancer chemotherapy. Active targeting… 
Review
2005
Review
2005
Direct T-cell stimulations by drugs--bypassing the innate immune system.
Review
2005
Review
2005
DIMSCAN: a microcomputer fluorescence-based cytotoxicity assay for preclinical testing of combination chemotherapy.
DIMSCAN is a semiautomatic fluorescence-based digital image microscopy system that quantifies relative total (using a DNA stain… 
Review
2002
Review
2002
Gene therapy for lysosomal storage disorders.
The lysosomal storage disorders (LSD) are monogenic inborn errors of metabolism with heterogeneous pathophysiology and clinical… 
Highly Cited
2001
Highly Cited
2001
Preliminary phase I results of G3139 (bcl-2 antisense oligonucleotide) therapy in combination with docetaxel in hormone-refractory prostate cancer.
Review
2000
Review
2000
Use of human prolactin as a therapeutic protein to potentiate immunohematopoietic function
2000
2000
A quantitative flow cytometry assay for the preclinical testing and pharmacological monitoring of rabbit antilymphocyte globulins (rATG).
1998
1998
Superantigen-targeted therapy: phase I escalating repeat dose trial of the fusion protein PNU-214565 in patients with advanced gastrointestinal malignancies.
Antibody-directed, superantigen-induced cytotoxicity has been shown to have potent in vitro and in vivo antitumor effects in… 
1998
1998
Preclinical and phase I clinical studies with the nonclassical antifolate thymidylate synthase inhibitor nolatrexed dihydrochloride given by prolonged administration in patients with solid tumors.
PURPOSE A phase I, multicenter trial of the thymidylate synthase (TS) inhibitor THYMITAQ (nolatrexed dihydrochloride; Agouron… 
Highly Cited
1994
Highly Cited
1994
Sequence dependence of paclitaxel (Taxol) combined with cisplatin or alkylators in human cancer cells.
Clinical trials combining paclitaxel with other active chemotherapy agents are currently underway. In vitro preclinical studies… 
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