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Drug Evaluation, Preclinical
Known as:
Preclinical Drug Evaluations
, Evaluation Studies, Drug, Pre-Clinical
, Screening, Drug
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Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
National Institutes of Health
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Related topics
Related topics
4 relations
Broader (1)
Screening procedure
Toxicity Tests
nursing therapy
standards characteristics
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Prodrugs of anthracyclines in cancer chemotherapy.
F. Kratz
,
A. Warnecke
,
Björn Schmid
,
Da-Eun Chung
,
M. Gitzel
Current Medicinal Chemistry
2006
Corpus ID: 28283623
Designing and developing truly tumor-specific prodrugs remains a challenge in the field of cancer chemotherapy. Active targeting…
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Review
2005
Review
2005
Direct T-cell stimulations by drugs--bypassing the innate immune system.
W. Pichler
Toxicology
2005
Corpus ID: 35775098
Review
2005
Review
2005
DIMSCAN: a microcomputer fluorescence-based cytotoxicity assay for preclinical testing of combination chemotherapy.
N. Keshelava
,
T. Frgala
,
J. Krejsa
,
O. Kalous
,
C. Reynolds
Methods in Molecular Medicine
2005
Corpus ID: 21528009
DIMSCAN is a semiautomatic fluorescence-based digital image microscopy system that quantifies relative total (using a DNA stain…
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Review
2002
Review
2002
Gene therapy for lysosomal storage disorders.
J. Barranger
,
E. Novelli
Expert Opinion on Biological Therapy
2002
Corpus ID: 28941111
The lysosomal storage disorders (LSD) are monogenic inborn errors of metabolism with heterogeneous pathophysiology and clinical…
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Highly Cited
2001
Highly Cited
2001
Preliminary phase I results of G3139 (bcl-2 antisense oligonucleotide) therapy in combination with docetaxel in hormone-refractory prostate cancer.
A. Tolcher
Seminars in Oncology
2001
Corpus ID: 29226886
Review
2000
Review
2000
Use of human prolactin as a therapeutic protein to potentiate immunohematopoietic function
S. Richards
,
W. Murphy
Journal of Neuroimmunology
2000
Corpus ID: 2276865
2000
2000
A quantitative flow cytometry assay for the preclinical testing and pharmacological monitoring of rabbit antilymphocyte globulins (rATG).
X. Preville
,
L. Nicolas
,
M. Flacher
,
J. Revillard
JIM - Journal of Immunological Methods
2000
Corpus ID: 34538841
1998
1998
Superantigen-targeted therapy: phase I escalating repeat dose trial of the fusion protein PNU-214565 in patients with advanced gastrointestinal malignancies.
R. Alpaugh
,
J. Schultz
,
+7 authors
L. Weiner
Clinical Cancer Research
1998
Corpus ID: 22141541
Antibody-directed, superantigen-induced cytotoxicity has been shown to have potent in vitro and in vivo antitumor effects in…
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1998
1998
Preclinical and phase I clinical studies with the nonclassical antifolate thymidylate synthase inhibitor nolatrexed dihydrochloride given by prolonged administration in patients with solid tumors.
I. Rafi
,
A. Boddy
,
+9 authors
A. Calvert
Journal of Clinical Oncology
1998
Corpus ID: 32445546
PURPOSE A phase I, multicenter trial of the thymidylate synthase (TS) inhibitor THYMITAQ (nolatrexed dihydrochloride; Agouron…
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Highly Cited
1994
Highly Cited
1994
Sequence dependence of paclitaxel (Taxol) combined with cisplatin or alkylators in human cancer cells.
J. Liebmann
,
J. Fisher
,
D. Teague
,
J. Cook
Oncology Research
1994
Corpus ID: 39761377
Clinical trials combining paclitaxel with other active chemotherapy agents are currently underway. In vitro preclinical studies…
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