Drug Evaluation, Preclinical

Known as: Preclinical Drug Evaluations, Evaluation Studies, Drug, Pre-Clinical, Screening, Drug 
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
National Institutes of Health

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Screening procedure
Toxicity Testsnursing therapystandards characteristics

Papers overview

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Highly Cited
2012
Highly Cited
2012
Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation.
UNLABELLED No specific drugs are currently available against hepatitis delta virus (HDV), a defective virus leading to the most… (More)
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Review
2011
Review
2011
From research to phase III: preclinical, industrial and clinical development of the Sanofi Pasteur tetravalent dengue vaccine.
Dengue vaccine development has reached a major milestone with the initiation, in 2010, of the first phase III clinical trial to… (More)
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Highly Cited
2010
Highly Cited
2010
Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP).
BACKGROUND MLN8237 is a small molecule inhibitor of Aurora Kinase A (AURKA) that is currently in early phase clinical testing… (More)
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Highly Cited
2008
Highly Cited
2008
DrugBank: a knowledgebase for drugs, drug actions and drug targets
DrugBank is a richly annotated resource that combines detailed drug data with comprehensive drug target and drug action… (More)
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Review
2008
Review
2008
Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development
The potential to generate virtually any differentiated cell type from embryonic stem cells (ESCs) offers the possibility to… (More)
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Highly Cited
2008
Highly Cited
2008
Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program.
BACKGROUND SCH 717454 (19D12) is a fully human antibody directed against the insulin-like growth factor 1 receptor (IGF-1R… (More)
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Highly Cited
2007
Highly Cited
2007
"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics.
The CD28-specific mAb TGN1412 rapidly caused a life-threatening "cytokine storm" in all six healthy volunteers in the Phase I… (More)
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Highly Cited
2006
Highly Cited
2006
DrugBank: a comprehensive resource for in silico drug discovery and exploration
DrugBank is a unique bioinformatics/cheminformatics resource that combines detailed drug (i.e. chemical) data with comprehensive… (More)
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Review
2006
Review
2006
FLT3 mutations: biology and treatment.
  • Donald Small
  • Hematology. American Society of Hematology…
  • 2006
FLT3 is a receptor tyrosine kinase with important roles in hematopoietic stem/progenitor cell survival and proliferation. It is… (More)
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Review
2004
Review
2004
Orthotopic models of cancer for preclinical drug evaluation: advantages and disadvantages.
Considering the enormous effort that has taken place over the years to discover new chemotherapeutic drugs for treating the… (More)
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