• Publications
  • Influence
Delayed Drug Hypersensitivity Reactions
  • W. Pichler
  • Medicine
  • Annals of Internal Medicine
  • 21 October 2003
Drug-induced adverse reactions are a major health problem (1-3). Most adverse effects, so-called type A reactions, are due to the pharmacologic action of a drug. Idiosyncratic and immune-mediatedExpand
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The lymphocyte transformation test in the diagnosis of drug hypersensitivity
Diagnosis of drug hypersensitivity is difficult, as an enormous amount of different drugs can elicit various immune‐mediated diseases with distinct pathomechanism. The lymphocyte transformation testExpand
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General considerations for skin test procedures in the diagnosis of drug hypersensitivity
K. Brockow, A. Romano, M. Blanca, J. Ring, W. Pichler, P. Demoly Klinik und Poliklinik fur Dermatologie und Allergologie, Muenchen, Germany; Department of Internal Medicine and Geriatrics, UCSC,Expand
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  • PDF
International Consensus on drug allergy
When drug reactions resembling allergy occur, they are called drug hypersensitivity reactions (DHRs) before showing the evidence of either drug‐specific antibodies or T cells. DHRs may be allergic orExpand
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Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations
A drug provocation test (DPT) is the controlled administration of a drug in order to diagnose drug hypersensitivity reactions. DPTs are performed under medical surveillance, whether this drug is anExpand
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Diagnosis of immediate allergic reactions to beta‐lactam antibiotics
Allergic reactions to betalactams are the most common cause of adverse drug reactions mediated by specific immunological mechanisms. Reactions may be induced by all betalactams currently available,Expand
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Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures.
The mechanisms of bee venom immunotherapy (VIT) are largely unknown. The aim of this study was to follow the changes of T cell cytokine secretion during the course of VIT. Ten bee venom-allergicExpand
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The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity
Background The diagnosis of a drag allergy is mainly based upon a very detailed history and the clinical findings. In addition, several in vitro or in vivo tests can be performed to demonstrate aExpand
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Delayed drug hypersensitivity reactions – new concepts
Immune reactions to small molecular compounds such as drugs can cause a variety of diseases mainly involving skin, but also liver, kidney, lungs and other organs. In addition to the well‐knownExpand
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Adverse side‐effects to biological agents
Biological agents‐like cytokines, monoclonal antibodies and fusion proteins are widely used in anti‐inflammatory and tumour therapy. They are highly efficient in certain diseases, but can cause aExpand
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