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Drug Discovery

Known as: Discovery, Drug, discoveries drug, discovery drug 
The process of finding chemicals for potential therapeutic use.
National Institutes of Health

Related topics

Related topics

5 relations
BioprospectingEducational aspectsHigh-Throughput Screening Assayslegislation & jurisprudence

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
BackgroundModern medicine often clashes with traditional medicine such as Chinese herbal medicine because of the little… 
Highly Cited
2011
Highly Cited
2011
LigPlot+: Multiple Ligand-Protein Interaction Diagrams for Drug Discovery
We describe a graphical system for automatically generating multiple 2D diagrams of ligand-protein interactions from 3D… 
Highly Cited
2011
Highly Cited
2011
ChEMBL: a large-scale bioactivity database for drug discovery
ChEMBL is an Open Data database containing binding, functional and ADMET information for a large number of drug-like bioactive… 
Review
2011
Review
2011
Principles of early drug discovery
Developing a new drug from original idea to the launch of a finished product is a complex process which can take 12–15 years and… 
Review
2008
Review
2008
Network pharmacology: the next paradigm in drug discovery.
  • A. Hopkins
  • Nature Chemical Biology
  • 2008
  • Corpus ID: 1450172
The dominant paradigm in drug discovery is the concept of designing maximally selective ligands to act on individual drug targets… 
Review
2005
Review
2005
The evolving role of natural products in drug discovery
Natural products and their derivatives have historically been invaluable as a source of therapeutic agents. However, in the past… 
Review
2004
Review
2004
Docking and scoring in virtual screening for drug discovery: methods and applications
Computational approaches that 'dock' small molecules into the structures of macromolecular targets and 'score' their potential… 
Review
2001
Review
2001
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.
Highly Cited
2000
Highly Cited
2000
Drug discovery: a historical perspective.
Driven by chemistry but increasingly guided by pharmacology and the clinical sciences, drug research has contributed more to the… 
Highly Cited
1990
Highly Cited
1990
New colorimetric cytotoxicity assay for anticancer-drug screening.
We have developed a rapid, sensitive, and inexpensive method for measuring the cellular protein content of adherent and… 
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