Drug Design

Known as: design drug, Design, Drug, Designs, Drug 
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Type III secretion systems (T3SSs) are protein transport nanomachines that are found in Gram-negative bacterial pathogens and… (More)
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Highly Cited
2014
Highly Cited
2014
DrugBank (http://www.drugbank.ca) is a comprehensive online database containing extensive biochemical and pharmacological… (More)
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Highly Cited
2008
Highly Cited
2008
DrugBank is a richly annotated resource that combines detailed drug data with comprehensive drug target and drug action… (More)
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Review
2007
Review
2007
Since the early 1990s, several technological and scientific advances — such as combinatorial chemistry, high-throughput screening… (More)
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Review
2007
Review
2007
Many potential drugs that specifically target a particular protein considered to underlie a given disease have been found to be… (More)
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Highly Cited
2006
Highly Cited
2006
DrugBank is a unique bioinformatics/cheminformatics resource that combines detailed drug (i.e. chemical) data with comprehensive… (More)
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Review
2005
Review
2005
Despite considerable progress in genome- and proteome-based high-throughput screening methods and rational drug design, the… (More)
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Review
2002
Review
2002
Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of these defects chemotherapy often fails… (More)
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Review
1992
Review
1992
Most drugs have been discovered in random screens or by exploiting information about macromolecular receptors. One source of this… (More)
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Highly Cited
1990
Highly Cited
1990
A FORTRAN 77 computer program has been written to aid with macromolecular modeling and drug design. Called WHAT IF, it provides… (More)
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