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Dopal

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1960-2018
024619602018

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1 relation

Broader (1)

Levodopa

Related mentions per year

Related mentions per year

1938-2018
19401960198020002020
Dopal
Levodopa

Papers overview

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2016
2016
Toxic Dopamine Metabolite DOPAL Forms an Unexpected Dicatechol Pyrrole Adduct with Lysines of α-Synuclein.
Parkinson's disease has long been known to involve the loss of dopaminergic neurons in the substantia nigra and the coincidental… (More)
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2015
2015
Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL).
Oxidative deamination of dopamine produces the highly toxic aldehyde 3,4-dihydroxyphenylacetaldehyde (DOPAL), enhanced production… (More)
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2014
2014
Divalent metal ions enhance DOPAL-induced oligomerization of alpha-synuclein.
Parkinson disease (PD) features profound striatal dopamine depletion and Lewy bodies containing abundant precipitated alpha… (More)
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2013
2013
Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease.
Intra-neuronal metabolism of dopamine (DA) begins with production of 3,4-dihydroxyphenylacetaldehyde (DOPAL),which is toxic… (More)
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2010
2010
The Neurotoxicity of DOPAL: Behavioral and Stereological Evidence for Its Role in Parkinson Disease Pathogenesis
BACKGROUND The etiology of Parkinson disease (PD) has yet to be fully elucidated. We examined the consequences of injections of 3… (More)
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2003
2003
3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson's disease pathogenesis.
In Parkinson's disease (PD), there is a highly selective loss of dopamine (DA) neurons in the substantia nigra (SN) greater than… (More)
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2001
2001
Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria.
Parkinson's disease (PD) is a major cause of age-related morbidity and mortality, present in nearly 1% of individuals at ages 70… (More)
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2001
2001
3,4-Dihydroxyphenylacetaldehyde and hydrogen peroxide generate a hydroxyl radical: possible role in Parkinson's disease pathogenesis.
3,4-Dihydroxyphenylacetaldehyde (DOPAL) and 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL), the monoamine oxidase (MAO) metabolites… (More)
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1987
1987
Human brain aldehyde dehydrogenase: activity with DOPAL and isozyme distribution.
Aldehyde dehydrogenase (ALDH, EC 1.2.1.3), has been shown to be the most important enzyme for DOPAL metabolism in human brain… (More)
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1987
1987
Metabolism of biogenic aldehydes in isolated human blood cells, platelets and in plasma.
The metabolism of biogenic aldehydes was measured in different human blood fractions. Isolated erythrocytes, leukocytes… (More)
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