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Dopal

 
National Institutes of Health

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Broader (1)

Levodopa

Papers overview

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Review
2018
Review
2018
Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by elevated concentrations of glucose in the blood. The… Expand
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2015
2015
Gender differences in plasma and urine metabolites from Sprague–Dawley rats after oral administration of normal and high doses of hydroxytyrosol, hydroxytyrosol acetate, and DOPAC
PurposeTo date, several in vitro and in vivo studies have shown phenolic compounds occurring naturally in olives and olive oil to… Expand
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2014
2014
Divalent metal ions enhance DOPAL-induced oligomerization of alpha-synuclein
Parkinson disease (PD) features profound striatal dopamine depletion and Lewy bodies containing abundant precipitated alpha… Expand
Highly Cited
2013
Highly Cited
2013
Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease
Intra‐neuronal metabolism of dopamine (DA) begins with production of 3,4‐dihydroxyphenylacetaldehyde (DOPAL), which is toxic… Expand
Highly Cited
2011
Highly Cited
2011
Oxidation of 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopaminergic Metabolite, to a Semiquinone Radical and an ortho-Quinone*
The oxidation and toxicity of dopamine is believed to contribute to the selective neurodegeneration associated with Parkinson… Expand
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Highly Cited
2010
Highly Cited
2010
The Neurotoxicity of DOPAL: Behavioral and Stereological Evidence for Its Role in Parkinson Disease Pathogenesis
Background The etiology of Parkinson disease (PD) has yet to be fully elucidated. We examined the consequences of injections of 3… Expand
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Highly Cited
2003
Highly Cited
2003
3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson’s disease pathogenesis
In Parkinson's disease (PD), there is a highly selective loss of dopamine (DA) neurons in the substantia nigra (SN) greater than… Expand
Highly Cited
2001
Highly Cited
2001
3,4-Dihydroxyphenylacetaldehyde and hydrogen peroxide generate a hydroxyl radical: possible role in Parkinson's disease pathogenesis.
3,4-Dihydroxyphenylacetaldehyde (DOPAL) and 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL), the monoamine oxidase (MAO) metabolites… Expand
Highly Cited
2000
Highly Cited
2000
Metabolic stress in PC12 cells induces the formation of the endogenous dopaminergic neurotoxin, 3,4‐dihydroxyphenylacetaldehyde
3,4‐Dihydroxyphenylacetaldehyde (DOPAL) has been reported to be a toxic metabolite formed by the oxidative‐deamination of… Expand
Highly Cited
2000
Highly Cited
2000
3,4-Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12 cells
3,4-Dihydroxyphenylacetaldehyde (DOPAL) is a toxic metabolite formed by the oxidative deamination of dopamine. This aldehyde is… Expand
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