Dopal

Parkinson's disease has long been known to involve the loss of dopaminergic neurons in the substantia nigra and the coincidental… Expand

Parkinson disease (PD) features profound striatal dopamine depletion and Lewy bodies containing abundant precipitated alpha… Expand

Intra-neuronal metabolism of dopamine (DA) begins with production of 3,4-dihydroxyphenylacetaldehyde (DOPAL),which is toxic… Expand

The oxidation and toxicity of dopamine is believed to contribute to the selective neurodegeneration associated with Parkinson… Expand

Background The etiology of Parkinson disease (PD) has yet to be fully elucidated. We examined the consequences of injections of 3… Expand

In Parkinson's disease (PD), there is a highly selective loss of dopamine (DA) neurons in the substantia nigra (SN) greater than… Expand

3,4-Dihydroxyphenylacetaldehyde (DOPAL) and 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL), the monoamine oxidase (MAO) metabolites… Expand

Parkinson's disease (PD) is a major cause of age-related morbidity and mortality, present in nearly 1% of individuals at ages 70… Expand

3,4-Dihydroxyphenylacetaldehyde (DOPAL) is a toxic metabolite formed by the oxidative deamination of dopamine. This aldehyde is… Expand

3,4-Dihydroxyphenylacetaldehyde (DOPAL) has been reported to be a toxic metabolite formed by the oxidative-deamination of… Expand