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Dopal

 
National Institutes of Health

Papers overview

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2016
2016
Parkinson's disease has long been known to involve the loss of dopaminergic neurons in the substantia nigra and the coincidental… Expand
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2014
2014
Parkinson disease (PD) features profound striatal dopamine depletion and Lewy bodies containing abundant precipitated alpha… Expand
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Highly Cited
2013
Highly Cited
2013
Intra-neuronal metabolism of dopamine (DA) begins with production of 3,4-dihydroxyphenylacetaldehyde (DOPAL),which is toxic… Expand
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Highly Cited
2011
Highly Cited
2011
The oxidation and toxicity of dopamine is believed to contribute to the selective neurodegeneration associated with Parkinson… Expand
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Highly Cited
2010
Highly Cited
2010
Background The etiology of Parkinson disease (PD) has yet to be fully elucidated. We examined the consequences of injections of 3… Expand
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Highly Cited
2003
Highly Cited
2003
In Parkinson's disease (PD), there is a highly selective loss of dopamine (DA) neurons in the substantia nigra (SN) greater than… Expand
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Highly Cited
2001
Highly Cited
2001
3,4-Dihydroxyphenylacetaldehyde (DOPAL) and 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL), the monoamine oxidase (MAO) metabolites… Expand
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Highly Cited
2001
Highly Cited
2001
Parkinson's disease (PD) is a major cause of age-related morbidity and mortality, present in nearly 1% of individuals at ages 70… Expand
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Highly Cited
2000
Highly Cited
2000
3,4-Dihydroxyphenylacetaldehyde (DOPAL) is a toxic metabolite formed by the oxidative deamination of dopamine. This aldehyde is… Expand
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Highly Cited
2000
Highly Cited
2000
3,4-Dihydroxyphenylacetaldehyde (DOPAL) has been reported to be a toxic metabolite formed by the oxidative-deamination of… Expand
Is this relevant?