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Dihydroneopterin aldolase

National Institutes of Health

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Aldehyde-Lyases

Papers overview

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2009
2009
6-Pyruvoyltetrahydropterin Synthase Paralogs Replace the Folate Synthesis Enzyme Dihydroneopterin Aldolase in Diverse Bacteria
ABSTRACT Dihydroneopterin aldolase (FolB) catalyzes conversion of dihydroneopterin to 6-hydroxymethyldihydropterin (HMDHP) in the… 
2007
2007
Mechanism of dihydroneopterin aldolase
Dihydroneopterin aldolase (DHNA) catalyzes both the cleavage of 7,8‐dihydro‐d‐neopterin (DHNP) to form 6‐hydroxymethyl‐7,8… 
2006
2006
A point mutation converts dihydroneopterin aldolase to a cofactor-independent oxygenase.
Dihydroneopterin aldolase (DHNA) catalyzes the conversion of 7,8-dihydroneopterin (1) to 6-hydroxymethyl-7,8-dihydropterin (4) in… 
2006
2006
Mechanism of dihydroneopterin aldolase: functional roles of the conserved active site glutamate and lysine residues.
Dihydroneopterin aldolase (DHNA) catalyzes the conversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropterin (HP… 
Highly Cited
2004
Highly Cited
2004
Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization.
Potent inhibitors of 7,8-dihydroneopterin aldolase (DHNA; EC 4.1.2.25) have been discovered using CrystaLEAD X-ray… 
2004
2004
Cloning of the Pneumocystis jirovecii trifunctional FAS gene and complementation of its DHPS activity in Escherichia coli.
Highly Cited
1998
Highly Cited
1998
Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from staphylococcus aureus
Dihydroneopterin aldolase catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin during the de… 
Highly Cited
1998
Highly Cited
1998
Sulfonamide Resistance in Streptococcus pyogenes Is Associated with Differences in the Amino Acid Sequence of Its Chromosomal Dihydropteroate Synthase
ABSTRACT Sulfonamide resistance in recent isolates of Streptococcus pyogenes was found to be associated with alterations of the… 
Highly Cited
1993
Highly Cited
1993
The multifunctional folic acid synthesis fas gene of Pneumocystis carinii encodes dihydroneopterin aldolase, hydroxymethyldihydropterin pyrophosphokinase and dihydropteroate synthase.
The nucleotide sequence of a folic acid synthesis (fas) gene from Pneumocystis carinii contains an open reading frame (ORF) that… 
1993
1993
A bifunctional protein in the folate biosynthetic pathway of Streptococcus pneumoniae with dihydroneopterin aldolase and hydroxymethyldihydropterin pyrophosphokinase activities
A protein encoded by sulD, one of four genes in a previously cloned folate biosynthetic operon of Streptococcus pneumoniae, had… 
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