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Epidemiology of drug-resistant malaria.
The various features of drug resistance in Plasmodium falciparum, including its determinants, current status in diverse geographical areas, molecular markers, and their implications are described. Expand
Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study.
An assay to quantify rare polymorphisms in parasite populations that uses a pooled deep-sequencing approach to score allele frequencies is developed and validated by evaluating mixtures of laboratory parasite strains, and used to screen P. falciparum parasites from >1100 African infections collected since 2002. Expand
Genetic diversity of Cryptosporidium spp. in cattle in Michigan: implications for understanding the transmission dynamics
The results of this study demonstrate the potential use of molecular methods in tracking the transmission of Cryptosporidium. Expand
Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy.
Artemisinin and its derivatives are endoperoxide-containing compounds which represent a promising new class of antimalarial drugs that show promise both as first-line agents and in the treatment of severe disease. Expand
Artemisinin: mechanisms of action, resistance and toxicity.
  • S. Meshnick
  • Biology, Medicine
  • International journal for parasitology
  • 4 December 2002
At high doses, artemisinin can be neurotoxic but toxicity has not been found in clinical studies, and the mechanism of neurotoxicity may be similar to the mechanisms of action. Expand
Resistance to Antimalarials in Southeast Asia and Genetic Polymorphisms in pfmdr1
ABSTRACT Resistance to antimalarial drugs is a public health problem worldwide. Molecular markers for drug-resistant malaria, such as pfcrt and pfmdr1 polymorphisms, could serve as usefulExpand
New insights into transmission, diagnosis, and drug treatment of Pneumocystis carinii pneumonia.
A case of P carinii infection that typifies clinical presentation in the era of the acquired immunodeficiency syndrome epidemic is presented and mutations in the target of sulfa drugs that appear to represent emerging resistance in PCarinii are identified. Expand
Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study.
The dramatic decline in efficacy of dihydroartemisinin-piperaquine compared with what was observed in a study at the same location in 2010 was strongly associated with a new triple mutation including the kelch13 Cys580Tyr substitution. Expand
Hematologic and clinical indices of malaria in a semi-immune population of western Thailand.
Thrombocytopenia is identified as a key indicator of malaria in these febrile patients and changes in hematologic profiles for a semi-immune population are defined. Expand
Dihydropteroate synthase polymorphisms in Pneumocystis carinii.
Six nucleotide changes were found in 6 human isolates; each was nonsynonymous and resulted in an amino acid change and are similar to those that cause sulfa resistance in other organisms. Expand