Skip to search formSkip to main contentSkip to account menu

Dihydrodipicolinate synthase

Known as: DHDPS enzyme, dihydrodipicolinic acid synthase, 4-hydroxy-tetrahydrodipicolinate synthase 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Hydro-Lyases
NPL genedihydrodipicolinate synthase activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Structure of the 4-hydroxy-tetrahydrodipicolinate synthase from the thermoacidophilic methanotroph Methylacidiphilum fumariolicum SolV and the phylogeny of the aminotransferase pathway.
The enzyme 4-hydroxy-tetrahydrodipicolinate synthase (DapA) is involved in the production of lysine and precursor molecules for… 
2019
2019
Transcriptome-derived investigation of biosynthesis of quinolizidine alkaloids in narrow-leafed lupin (Lupinus angustifolius L.) highlights candidate genes linked to iucundus locus
Unravelling the biosynthetic pathway of quinolizidine alkaloids (QAs), regarded as antinutritional compounds of narrow-leafed… 
2019
2019
Cloning and optimizing the expression of the DHDPS gene in the Medicago truncatula
Medicago truncatula seeds were cultured and developed in Thua Thien Hue province, Vietnam, and they were used as materials for… 
2018
2018
Mapping the uncharted water channel of dihydrodipicolinate synthase : a proposed mechanism of allostery.
................................................................................................................................. 2 Abbreviations ........................................................................................................................ 3 Chapter One: Introduction ..................................................................................................... 6 1.1 Allostery ..............................................................................................................................................................6 1.2 Lysine biosynthesis pathway ......................................................................................................................7 1.3 DHDPS .............................................................................................................................................................. 10 1.3.1 Background ............................................................................................................................................. 10 1.3.2 Structure of DHDPS ............................................................................................................................ 10 1.3.2.1 The catalytic site ........................................................................................................... 11 1.3.2.2 The Allosteric site ........................................................................................................ 12 1.3.2.3 The A,B/C,D interfaces .............................................................................................. 12 1.3.2.4 The A,D/B,C interfaces .............................................................................................. 13 1.3.3 DHDPS-catalysed reaction ................................................................................................................ 13 1.3.4 DHDPS is allosterically inhibited by lysine ................................................................................. 14 1.4 Motivation for this research .................................................................................................................... 15 1.5 Aims and hypothesis ................................................................................................................................... 17 1.6 References ........................................................................................................................................................ 17 Chapter Two: Molecular Biology and Protein Purification................................................. 23 2. 
2016
2016
Identification of potential leads against 4-hydroxytetrahydrodipicolinate synthase from Mycobacterium tuberculosis
4-hydroxy-tetrahydrodipicolinate synthase (DHDPS) is an important enzyme needed for the biosynthesis of lysine and many more key… 
2013
2013
Regulatory mechanisms after short- and long-term perturbed lysine biosynthesis in the aspartate pathway: the need for isogenes in Arabidopsis thaliana.
The aspartate-derived amino acid pathway in plants is an intensively studied metabolic pathway, because of the biosynthesis of… 
2010
2010
Disruption of quaternary structure in Escherichia coli dihydrodipicolinate synthase (DHDPS) generates a functional monomer that is no longer inhibited by lysine.
Highly Cited
2005
Highly Cited
2005
Role of arginine 138 in the catalysis and regulation of Escherichia coli dihydrodipicolinate synthase.
In plants and bacteria, the branch point of (S)-lysine biosynthesis is the condensation of (S)-aspartate-beta-semialdehyde [(S… 
Highly Cited
2004
Highly Cited
2004
The crystal structure of three site-directed mutants of Escherichia coli dihydrodipicolinate synthase: further evidence for a catalytic triad.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)