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Dihydrodipicolinate synthase

Known as: DHDPS enzyme, dihydrodipicolinic acid synthase, 4-hydroxy-tetrahydrodipicolinate synthase 
 
National Institutes of Health

Papers overview

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2020
2020
The enzyme 4-hydroxy-tetrahydrodipicolinate synthase (DapA) is involved in the production of lysine and precursor molecules for… Expand
2019
2019
Unravelling the biosynthetic pathway of quinolizidine alkaloids (QAs), regarded as antinutritional compounds of narrow-leafed… Expand
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2019
2019
Medicago truncatula seeds were cultured and developed in Thua Thien Hue province, Vietnam, and they were used as materials for… Expand
2018
2018
................................................................................................................................. 2 Abbreviations ........................................................................................................................ 3 Chapter One: Introduction ..................................................................................................... 6 1.1 Allostery ..............................................................................................................................................................6 1.2 Lysine biosynthesis pathway ......................................................................................................................7 1.3 DHDPS .............................................................................................................................................................. 10 1.3.1 Background ............................................................................................................................................. 10 1.3.2 Structure of DHDPS ............................................................................................................................ 10 1.3.2.1 The catalytic site ........................................................................................................... 11 1.3.2.2 The Allosteric site ........................................................................................................ 12 1.3.2.3 The A,B/C,D interfaces .............................................................................................. 12 1.3.2.4 The A,D/B,C interfaces .............................................................................................. 13 1.3.3 DHDPS-catalysed reaction ................................................................................................................ 13 1.3.4 DHDPS is allosterically inhibited by lysine ................................................................................. 14 1.4 Motivation for this research .................................................................................................................... 15 1.5 Aims and hypothesis ................................................................................................................................... 17 1.6 References ........................................................................................................................................................ 17 Chapter Two: Molecular Biology and Protein Purification................................................. 23 2. 
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2016
2016
4-hydroxy-tetrahydrodipicolinate synthase (DHDPS) is an important enzyme needed for the biosynthesis of lysine and many more key… Expand
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2013
2013
The aspartate-derived amino acid pathway in plants is an intensively studied metabolic pathway, because of the biosynthesis of… Expand
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2010
2010
Escherichia coli dihydrodipicolinate synthase (DHDPS, E.C. 4.2.1.52), a natively homotetrameric enzyme was converted to a… Expand
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Highly Cited
2005
Highly Cited
2005
In plants and bacteria, the branch point of (S)-lysine biosynthesis is the condensation of (S)-aspartate-beta-semialdehyde [(S… Expand
Highly Cited
2004
Highly Cited
2004
Dihydrodipicolinate synthase (DHDPS, EC 4.2.1.52) catalyses the branchpoint reaction of lysine biosynthesis in plants and… Expand