Digestive System Injury

Worldwide osteoarthritis (OA) affects more than 9.6% of men and 18% of women older that 60 years. Treatment for OA often requires… (More)

BACKGROUND & AIMS Gastrointestinal damage caused by nonsteroidal anti-inflammatory drugs (NSAIDs) remains a significant clinical… (More)

BACKGROUND & AIMS Bisphosphonates are effective treatment for osteoporosis, but upper gastrointestinal injury associated with… (More)

Glucagon-like peptides (GLPs) are secreted from enteroendocrine cells in the gastrointestinal tract. GLP-1 actions regulate blood… (More)

Keratinocyte growth factor (KGF) stimulates the proliferation and differentiation of epithelial cells including those of the… (More)

Prostaglandins are generated through two isoforms of the enzyme cyclooxygenase, the constitutively expressed cyclooxygenase (Cox… (More)

Nonaspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used drugs in many countries. Use of the… (More)

pS2 is a member of the trefoil peptide family, all of which are overexpressed at sites of gastrointestinal injury. We… (More)

The molecular basis of the injurious actions of non-steroidal anti-inflammatory drugs (NSAIDs) on the gastrointestinal (GI) tract… (More)

BACKGROUND/AIMS The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is limited by their ability to induce gastrointestinal… (More)