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Differentiation Inducer

Known as: Differentiating Agents, Differentiation Agents 
An agent that induces the differentiation or maturation of cells, specifically neoplastic cells, resulting in decreases in tumor growth and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia
Differentiating agents have been proposed to overcome the impaired cellular differentiation in acute myeloid leukemia (AML… Expand
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Highly Cited
2004
Highly Cited
2004
Very High Frequency of Hypermethylated Genes in Breast Cancer Metastasis to the Bone, Brain, and Lung
Purpose: Most often it is not the primary tumor, but metastasis to distant organs that results in the death of breast cancer… Expand
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Review
2003
Review
2003
Tumor cell senescence in cancer treatment.
Cell senescence is broadly defined as the physiological program of terminal growth arrest, which can be triggered by alterations… Expand
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Highly Cited
2002
Highly Cited
2002
Differential regulation of Cbfa1/Runx2 and osteocalcin gene expression by vitamin-D3, dexamethasone, and local growth factors in primary human osteoblasts.
Core binding factor alpha 1 (Cbfa1) is an osteoblast-specific transcription factor essential to develop a mature osteoblast… Expand
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Highly Cited
1999
Highly Cited
1999
A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents.
Exposure of human tumor cell lines to different chemotherapeutic drugs, ionizing radiation, and differentiating agents induced… Expand
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Review
1997
Review
1997
Retinoid X receptors.
  • A. Rowe
  • The international journal of biochemistry & cell…
  • 1997
    • Corpus ID: 11659020
Retinoids are metabolites of retinol (vitamin A), which act as signalling molecules in embryogenesis and as stimulators of… Expand
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Highly Cited
1996
Highly Cited
1996
Annual hazard rates of recurrence for breast cancer after primary therapy.
PURPOSE To determine if the long-term increase of recurrence for breast cancer is stable or slowly decreasing, or if it ever… Expand
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Highly Cited
1996
Highly Cited
1996
Differences in the state of differentiation of THP-1 cells induced by phorbol ester and 1,25-dihydroxyvitamin D3.
Human THP-1 leukemia cells differentiate along the monocytic lineage following exposure to phorbol-12-myristate-13-acetate (PMA… Expand
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Review
1993
Review
1993
Acute promyelocytic leukemia.
Perhaps the most important advance in this field is not the specific actions of all-trans-retinoic acid in acute promyelocytic… Expand
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Review
1993
Review
1993
Mullerian inhibiting substance: a gonadal hormone with multiple functions.
Mullerian inhibiting substance (MIS) is the gonadal hormone that causes regression of the Mullerian ducts, the anlagen of the… Expand
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