Differentiation Inducer

Known as: Differentiating Agents, Differentiation Agents 
An agent that induces the differentiation or maturation of cells, specifically neoplastic cells, resulting in decreases in tumor growth and… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia
Differentiating agents have been proposed to overcome the impaired cellular differentiation in acute myeloid leukemia (AML… (More)
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Highly Cited
2009
Highly Cited
2009
The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation.
Many microRNAs (miRNAs), posttranscriptional regulators of numerous cellular processes and developmental events, are… (More)
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Review
2003
Review
2003
Tumor cell senescence in cancer treatment.
Cell senescence is broadly defined as the physiological program of terminal growth arrest, which can be triggered by alterations… (More)
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Highly Cited
1996
Highly Cited
1996
Differences in the state of differentiation of THP-1 cells induced by phorbol ester and 1,25-dihydroxyvitamin D3.
Human THP-1 leukemia cells differentiate along the monocytic lineage following exposure to phorbol-12-myristate-13-acetate (PMA… (More)
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Highly Cited
1996
Highly Cited
1996
Annual hazard rates of recurrence for breast cancer after primary therapy.
PURPOSE To determine if the long-term increase of recurrence for breast cancer is stable or slowly decreasing, or if it ever… (More)
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Highly Cited
1996
Highly Cited
1996
Developmental expression in the mouse nervous system of the p493F12 SAP kinase.
Mitogen-activated protein (MAP) kinases are proline-directed, serine/threonine kinases that respond to a variety of extracellular… (More)
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Review
1993
Review
1993
Acute promyelocytic leukemia.
Perhaps the most important advance in this field is not the specific actions of all-trans-retinoic acid in acute promyelocytic… (More)
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Highly Cited
1993
Highly Cited
1993
Induction of Rev-ErbA alpha, an orphan receptor encoded on the opposite strand of the alpha-thyroid hormone receptor gene, during adipocyte differentiation.
Rev-ErbA alpha (Rev-Erb) is a nuclear hormone receptor-related transcriptional activator that is encoded on the noncoding strand… (More)
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1989
1989
Purification and characterization of human lysosomal membrane glycoproteins.
Two human cell lysosomal membrane glycoproteins of approximately 120 kDa, hLAMP-1 and hLAMP-2, were identified by use of… (More)
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Review
1984
Review
1984
Heterogeneity of human colon carcinoma
In order to better understand colon cancer, a model system reflecting the heterogenous nature of this disease was developed and… (More)
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