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Differentiation Inducer

Known as: Differentiating Agents, Differentiation Agents 
An agent that induces the differentiation or maturation of cells, specifically neoplastic cells, resulting in decreases in tumor growth and… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Regulation of C/EBPβ and resulting functions in cells of the monocytic lineage.
Highly Cited
2010
Highly Cited
2010
Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia
Differentiating agents have been proposed to overcome the impaired cellular differentiation in acute myeloid leukemia (AML… 
Highly Cited
2002
Highly Cited
2002
Differential regulation of Cbfa1/Runx2 and osteocalcin gene expression by vitamin‐D3, dexamethasone, and local growth factors in primary human osteoblasts
Core binding factor alpha 1 (Cbfa1) is an osteoblast‐specific transcription factor essential to develop a mature osteoblast… 
Highly Cited
1999
Highly Cited
1999
Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate
SummaryA series of hydroxamates, which are not metalloprotease inhibitors, have been found to be selectively toxic to a range of… 
Highly Cited
1998
Highly Cited
1998
Action of 1,25(OH)2D3 on the cell cycle genes, cyclin D1, p21 and p27 in MCF-7 cells
Review
1998
Review
1998
The emerging role of retinoids and retinoic acid metabolism blocking agents in the treatment of cancer
Although significant advances have been made in the treatment of some malignancies, the prognosis of patients with metastatic… 
Highly Cited
1996
Highly Cited
1996
Cell type-specific fusion cofactors determine human immunodeficiency virus type 1 tropism for T-cell lines versus primary macrophages
Work in this laboratory previously demonstrated that the tropism of different human immunodeficiency type 1 isolates for… 
Highly Cited
1992
Highly Cited
1992
Immortal rat hippocampal cell lines exhibit neuronal and glial lineages and neurotrophin gene expression.
Clonal cell lines of rat embryonic hippocampal origin have been developed by using retroviral transduction of temperature… 
Highly Cited
1989
Highly Cited
1989
Purification and characterization of human lysosomal membrane glycoproteins.
Highly Cited
1987
Highly Cited
1987
Effects of recombinant IL-3, GM-CSF, and G-CSF on proliferation of leukemic clonogenic cells in short-term and long-term cultures.
To further define the growth factors required for the in vitro proliferation of acute myeloblastic leukemic (AML) cells, we have… 
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