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Diabetic Embryopathy

A condition in which the offspring of a mother with diabetes predating pregnancy develops congenital malformations that can affect multiple organ… 
National Institutes of Health

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Related topics

2 relations
Fetal DiseasesPerinatal Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Caspase-8: a key role in the pathogenesis of diabetic embryopathy.
Maternal diabetes causes neural tube defects in embryos, which are associated with increased apoptosis in the neuroepithelium… 
2008
2008
Wnt signaling in caudal dysgenesis and diabetic embryopathy.
BACKGROUND Congenital defects are a major complication of diabetic pregnancy, and the leading cause of infant death in the first… 
Highly Cited
2007
Highly Cited
2007
Expression of the gene encoding the high-Km glucose transporter 2 by the early postimplantation mouse embryo is essential for neural tube defects associated with diabetic embryopathy
Aims/hypothesisExcess glucose transport to embryos during diabetic pregnancy causes congenital malformations. The early… 
Highly Cited
2002
Highly Cited
2002
Polymorphic susceptibility to the molecular causes of neural tube defects during diabetic embryopathy.
Previously, we demonstrated that neural tube defects (NTDs) are significantly increased in a mouse model of diabetic pregnancy… 
Review
1999
Review
1999
Maternal fuels, diabetic embryopathy: pathomechanisms and prevention.
Congenital malformations remain the major cause of morbidity and mortality among the offspring of women with diabetes. Animal and… 
Highly Cited
1998
Highly Cited
1998
Teratogenicity of 3-deoxyglucosone and diabetic embryopathy.
The increased rate of embryonic dysmorphogenesis in diabetic pregnancy is correlated with the severity and duration of the… 
Highly Cited
1996
Highly Cited
1996
Dietary polyunsaturated fatty acid prevents malformations in offspring of diabetic rats.
1994
1994
In vitro study of the carry-over effect associated with early diabetic embryopathy in the rat
SummaryEmbryos were recovered from diabetic rats on day 5 of pregnancy and incubated in vitro for up to 72 h. Compared to control… 
Highly Cited
1986
Highly Cited
1986
Somatomedin Inhibitors From Diabetic Rat Serum Alter Growth and Development of Mouse Embryos in Culture
Offspring of diabetic humans and laboratory animals have been shown to have a higher incidence of congenital malformations with… 
Highly Cited
1985
Highly Cited
1985
Hyperglycemia-induced teratogenesis is mediated by a functional deficiency of arachidonic acid.
Congenital malformations now represent the largest single cause of mortality in the infant of the diabetic mother. The mechanism… 
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