Dexmedetomidine

Known as: 1H-Imidazole, 4-(1-(2,3-dimethylphenyl)ethyl)-, (R)-, Dexmedetomidin, Dexmédétomidine 
An imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative properties. Dexmedetomidine selectively binds to… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
CONTEXT Long-term sedation with midazolam or propofol in intensive care units (ICUs) has serious adverse effects. Dexmedetomidine… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Neuroapoptosis is induced by the administration of anesthetic agents to the young. As alpha2 adrenoceptor signaling… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Dexmedetomidine, a highly selective alpha2-adrenoceptor agonist used for short-term sedation of mechanically… (More)
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Highly Cited
2004
Highly Cited
2004
DEXMEDETOMIDINE is a highly selective 2 adrenoceptor agonist that has sedative and analgesic properties with associated reduction… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND The authors investigated whether the sedative, or hypnotic, action of the general anesthetic dexmedetomidine (a… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND This study determined the responses to increasing plasma concentrations of dexmedetomidine in humans. METHODS Ten… (More)
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Highly Cited
2000
Highly Cited
2000
This research determined the safety and efficacy of two small-dose infusions of dexmedetomidine by evaluating sedation, analgesia… (More)
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Highly Cited
2000
Highly Cited
2000
STATEMENT OF FINDINGS: The respiratory effects of dexmedetomidine were retrospectively examined in 33 postsurgical patients… (More)
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Highly Cited
1999
Highly Cited
1999
Dexmedetomidine, a highly selective and potent alpha2-adrenergic agonist, has a potentially useful role as a sedative agent in… (More)
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Highly Cited
1992
Highly Cited
1992
Dexmedetomidine (DMED) is a novel clonidine-like compound known to have sedative, analgesic, and cardiovascular stabilizing… (More)
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