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Deregulation

Known as: Deregulated 
The act or process of removing restrictions and controls.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
University of Birmingham MYC activation and BCL2L11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs
Lymphomagenesis in the presence of deregulated MYC requires suppression of MYC - driven apoptosis, often through downregulation… 
Highly Cited
2009
Highly Cited
2009
Current smoking‐specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer
Cigarette smoking is the main risk factor for the development of squamous cell lung carcinoma (SCC). However, the smoking‐related… 
Highly Cited
2008
Highly Cited
2008
Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production.
Highly Cited
2003
Highly Cited
2003
Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643.
We hypothesized that the mouse liver tumor response to non-genotoxic carcinogens would involve some common early gene and protein… 
Highly Cited
2001
Highly Cited
2001
Subcellular localisation of cyclin D1 protein in colorectal tumours is associated with p21WAF1/CIP1 expression and correlates with patient survival
We investigated the expression of the cell cycle regulatory proteins cyclin D1 and p21WAF1/CIP1 (p21) in human colorectal… 
Highly Cited
1997
Highly Cited
1997
The distal GATA sequences of the sid1 promoter of Ustilago maydis mediate iron repression of siderophore production and interact directly with Urbs1, a GATA family transcription factor
The sid1 and urbs1 genes encode L‐ornithine N5‐oxygenase and a GATA family transcription regulator, respectively, for siderophore… 
Highly Cited
1997
Highly Cited
1997
Rapid induction of apoptosis by deregulated uptake of polyamine analogues.
Treatment of Chinese hamster ovary cells with alpha-difluoromethylornithine for 3 days, followed by exposure to cycloheximide… 
Review
1993
Review
1993
Gene and chromosomal alterations associated with the development of human gliomas
The development of a malignant tumor generally entails a series of events that damage the genome of a somatic cell and result in… 
Highly Cited
1993
Highly Cited
1993
Coding sequence of the overexpressed transcript of the putative oncogene PRAD1/cyclin D1 in two primary human tumors.
PRAD1 (cyclin D1) is a recently identified member of the family of cyclin genes, believed to play roles in regulating transitions… 
Review
1989
Review
1989
RB and the cell cycle: Entrance or exit?
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