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Deleterious Mutation

A mutation that is documented to be associated with risk of disease.
National Institutes of Health

Papers overview

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2013
2013
Can Synergistic Epistasis Halt Mutation Accumulation? Results from Numerical Simulation
The process of deleterious mutation accumulation is influenced by numerous biological factors, including the way in which the… 
2011
2011
Colorectal cancer cases with de novo germ-line mutations in MLH1, MSH2, and MSH6 from the Colon Cancer Family Registry.
3538 Background: Lynch syndrome is caused by a germ-line mutation in a DNA mismatch repair (MMR) gene. Carriers are at high risks… 
2010
2010
PARP inhibitors in BRCA 1 / BRCA 2 germline mutation carriers with ovarian and breast cancer
BRCA and poly-ADP ribose polymerase (PARP) regulate pathways of DNA repair. Due to the accumulation of mutations introduced by… 
2006
2006
Mutation analysis of BRCA 1 and BRCA 2 from 793 Korean patients with sporadic breast cancer
To investigate the role of BRCA1 and BRCA2mutations in Korean patients with sporadic breast cancer, 793 breast cancer patients… 
2002
2002
The Advantage of Sex in the RNA V i 4 6
When laboratory populations of the RNA bacteriophage 46 are subjected to intensified genetic drift, they experience a decline in… 
1999
1999
The effect of overdominance on characterizing deleterious mutations in large natural populations.
Alternatives to the mutation-accumulation approach have been developed to characterize deleterious genomic mutations. However… 
1999
1999
Advances in Brief Neurofibromatosis and Early Onset of Cancers in h MLH 1-deficient Children 1
Hereditary nonpolyposis colon cancer is a common hereditary disorder caused by the germ-line mutations of DNA mismatch repair… 
1989
1989
A population genetical model for sequence evolution under multiple types of mutation.
  • M. Iizuka
  • Genetical research
  • 1989
  • Corpus ID: 42965167
DNA sequencing and restriction mapping provide us with information on DNA sequence evolution within populations, from which the… 
1973
1973
Total number of individuals affected by a single sex-linked deleterious mutation in a finite population.
1967
1967
The evolution of selective advantage in a deleterious mutation.
ISHER (1928) put forward a theory of dominance that is still the subject of Fcontroversy. If a deleterious mutation is…