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Deep Sequencing

Known as: Deep Sequencings, Sequencing, Deep, Sequencings, Deep 
Techniques of nucleotide sequence analysis that increase the scale of operations enabling an increase in the depth of coverage (number of copies) to… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2008-2018
05020082018

Papers overview

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Review
2016
Review
2016
Noncoding RNA: Current Deep Sequencing Data Analysis Approaches and Challenges.
One of the most significant biological discoveries of the last decade is represented by the reality that the vast majority of the… (More)
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Highly Cited
2013
Highly Cited
2013
Full-Genome Deep Sequencing and Phylogenetic Analysis of Novel Human Betacoronavirus
A novel betacoronavirus associated with lethal respiratory and renal complications was recently identified in patients from… (More)
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Highly Cited
2012
Highly Cited
2012
The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging
In neurons, dendritic protein synthesis is required for many forms of long-term synaptic plasticity. The population of mRNAs that… (More)
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Highly Cited
2012
Highly Cited
2012
Whole Genome Deep Sequencing of HIV-1 Reveals the Impact of Early Minor Variants Upon Immune Recognition During Acute Infection
Deep sequencing technologies have the potential to transform the study of highly variable viral pathogens by providing a rapid… (More)
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Highly Cited
2011
Highly Cited
2011
MicroRNA Expression Signatures of Bladder Cancer Revealed by Deep Sequencing
BACKGROUND MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression. They are aberrantly expressed in… (More)
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Highly Cited
2011
Highly Cited
2011
Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins
Somatic mutations of mtDNA are implicated in the aging process, but there is no universally accepted method for their accurate… (More)
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Highly Cited
2010
Highly Cited
2010
Transmission of Single HIV-1 Genomes and Dynamics of Early Immune Escape Revealed by Ultra-Deep Sequencing
We used ultra-deep sequencing to obtain tens of thousands of HIV-1 sequences from regions targeted by CD8+ T lymphocytes from… (More)
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Highly Cited
2009
Highly Cited
2009
Quantitative Deep Sequencing Reveals Dynamic HIV-1 Escape and Large Population Shifts during CCR5 Antagonist Therapy In Vivo
High-throughput sequencing platforms provide an approach for detecting rare HIV-1 variants and documenting more fully… (More)
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Highly Cited
2009
Highly Cited
2009
Small RNA Deep Sequencing Reveals Role for Arabidopsis thaliana RNA-Dependent RNA Polymerases in Viral siRNA Biogenesis
RNA silencing functions as an important antiviral defense mechanism in a broad range of eukaryotes. In plants, biogenesis of… (More)
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Highly Cited
2008
Highly Cited
2008
Deep Sequencing Analysis of Small Noncoding RNA and mRNA Targets of the Global Post-Transcriptional Regulator, Hfq
Recent advances in high-throughput pyrosequencing (HTPS) technology now allow a thorough analysis of RNA bound to cellular… (More)
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