FAQ

Death Effector Domain

Known as: DED Domain, DED Domains, Death Effector Domains 
A homotypic protein interaction module of the death domain superfamily that is composed of a bundle of six alpha-helices. The death effector domain… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2016
0519972016

Related topics

Related topics

2 relations
aspects of radiation effectsphysiological aspects

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Death Effector Domain
physiological aspects
aspects of radiation effects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments.
Inflammasomes mediate inflammatory and cell death responses to pathogens and cellular stress signals via activation of… (More)
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Highly Cited
2012
Highly Cited
2012
A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death
Formation of the death-inducing signaling complex (DISC) is a critical step in death receptor-mediated apoptosis, yet the… (More)
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2011
2011
Peroxiredoxin 6 interferes with TRAIL-induced death-inducing signaling complex formation by binding to death effector domain caspase
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapeutic agent with cancer-selective… (More)
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2009
2009
Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules
Microtubule-perturbing drugs have become front-line chemotherapeutics, inducing cell-cycle crisis as a major mechanism of action… (More)
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2009
2009
The Death Effector Domains of Caspase-8 Induce Terminal Differentiation
The differentiation and senescence programs of metazoans play key roles in regulating normal development and preventing aberrant… (More)
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2004
2004
Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing
AbstractApoptin, a protein from chicken anemia virus without an apparent cellular homologue, can induce apoptosis in mammalian… (More)
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2002
2002
Identification and characterization of DEDD2, a death effector domain-containing protein.
A novel Death Effector Domain-containing protein was identified, DEDD2, which is closest in amino acid sequence homology to death… (More)
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2001
2001
Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription
The death effector domain (DED) is a protein/protein interaction domain only found in proteins that are involved in apoptosis… (More)
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2000
2000
Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD
RAIDD, a caspase recruitment domain (CARD) containing molecule, interacts with procaspase-2 in a CARD-dependent manner. This… (More)
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Highly Cited
1999
Highly Cited
1999
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
Death Effector Domains (DEDs) have been known to mediate the recruitment of Caspase 8 and its homologs to the aggregated death… (More)
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