Death Effector Domain

Known as: DED Domain, DED Domains, Death Effector Domains 
A homotypic protein interaction module of the death domain superfamily that is composed of a bundle of six alpha-helices. The death effector domain… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2016
0519972016

Papers overview

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2015
2015
Inflammasomes mediate inflammatory and cell death responses to pathogens and cellular stress signals via activation of… (More)
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Highly Cited
2012
Highly Cited
2012
Formation of the death-inducing signaling complex (DISC) is a critical step in death receptor-mediated apoptosis, yet the… (More)
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2011
2011
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapeutic agent with cancer-selective… (More)
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2009
2009
Microtubule-perturbing drugs have become front-line chemotherapeutics, inducing cell-cycle crisis as a major mechanism of action… (More)
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2009
2009
The differentiation and senescence programs of metazoans play key roles in regulating normal development and preventing aberrant… (More)
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2004
2004
AbstractApoptin, a protein from chicken anemia virus without an apparent cellular homologue, can induce apoptosis in mammalian… (More)
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2002
2002
A novel Death Effector Domain-containing protein was identified, DEDD2, which is closest in amino acid sequence homology to death… (More)
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2001
2001
The death effector domain (DED) is a protein/protein interaction domain only found in proteins that are involved in apoptosis… (More)
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2000
2000
RAIDD, a caspase recruitment domain (CARD) containing molecule, interacts with procaspase-2 in a CARD-dependent manner. This… (More)
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Highly Cited
1999
Highly Cited
1999
Death Effector Domains (DEDs) have been known to mediate the recruitment of Caspase 8 and its homologs to the aggregated death… (More)
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