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To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of… Expand Aims The DUSP9 locus on chromosome X was identified as a susceptibility locus for type 2 diabetes in a meta-analysis of European… Expand Aims/hypothesisRecent genome-wide association (GWA) studies and subsequent replication studies have greatly increased the number… Expand Aims/hypothesisBy combining multiple genome-wide association (GWA) studies and comprehensive replication efforts, 12 novel type 2… Expand By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European… Expand To understand possible causative roles of apoptosis gene regulation in age-related hearing loss (presbycusis), apoptotic gene… Expand OBJECTIVE
Data regarding signal transduction pathways in human tumors are largely confined to cell line studies to date. We have… Expand Prolonged use of glucocorticoids induces pronounced insulin resistance in vivo. In vitro, treatment of 3T3-L1 adipocytes with… Expand MAP kinase phosphatase-3 (MKP-3) dephosphorylates phosphotyrosine and phosphothreonine and inactivates selectively ERK family… Expand Extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK), and p38/RK/CSBP… Expand