A Novel Intergenic ETnII-β Insertion Mutation Causes Multiple Malformations in Polypodia Mice

@inproceedings{Lehoczky2013ANI,
  title={A Novel Intergenic ETnII-β Insertion Mutation Causes Multiple Malformations in Polypodia Mice},
  author={Jessica A. Lehoczky and Peedikayil E. Thomas and Kevin M. Patrie and Kailey M Owens and Lisa M. Villarreal and Kenneth A.A. Galbraith and Joe Washburn and Craig Norman Johnson and Bryant J Gavino and Alexander D. Borowsky and Kathleen J. Millen and Paul Wakenight and William M Law and Margaret L. Van Keuren and Galina B. Gavrilina and Elizabeth D. Hughes and Thomas Saunders and Lesil Brihn and Joseph H. Nadeau and Jeffrey W. Innis},
  booktitle={PLoS genetics},
  year={2013}
}
Mouse early transposon insertions are responsible for ~10% of spontaneous mutant phenotypes. We previously reported the phenotypes and genetic mapping of Polypodia, (Ppd), a spontaneous, X-linked dominant mutation with profound effects on body plan morphogenesis. Our new data shows that mutant mice are not born in expected Mendelian ratios secondary to loss… CONTINUE READING