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DU 145

A cell line made from human prostate cancer cells that is used in the laboratory to study the way prostate cancer cells grow.
National Institutes of Health

Papers overview

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Highly Cited
2019
Highly Cited
2019
Casticin inhibits human prostate cancer DU 145 cell migration and invasion via Ras/Akt/NF-κB signaling pathways.
Casticin, a polymethoxyflavone derived from natural plants, has biological activities including induction of cell apoptosis. In… 
2016
2016
Cytotoxic evaluation of different fractions of Salvia chorassanica Bunge on MCF-7 and DU 145 cell lines
Because of antimicrobial, antioxidant, and anticancer potential, Salvia chorassanica Bunge (Lamiaceae) has been considered as a… 
2014
2014
Upregulation of death receptor 5 and activation of caspase 8/3 play a critical role in ergosterol peroxide induced apoptosis in DU 145 prostate cancer cells
BackgroundThough ergosterol peroxide (EP) derived from Neungyi mushrooms (Sarcodon aspratus) was known to have cytotoxic… 
2011
2011
The roles of AIF and Endo G in the apoptotic effects of benzyl isothiocyanate on DU 145 human prostate cancer cells via the mitochondrial signaling pathway.
It is well known that the response of cancer cells to chemotherapeutic drugs involves the activation of apoptotic pathways… 
Highly Cited
2004
Highly Cited
2004
Vesicle traffic through intercellular bridges in DU 145 human prostate cancer cells
We detected cell‐to‐cell communication via intercellular bridges in DU 145 human prostate cancer cells by fluorescence microscopy… 
Highly Cited
2003
Highly Cited
2003
NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells.
Reactive oxygen species (ROS) appear to play an important role in regulating growth and survival of prostate cancer. However, the… 
2001
2001
Comparison of the malignant phenotype and genotype of the human androgen-independent cell line DU 145 and a subline derived from metastasis after orthotopic implantation in nude mice.
Highly Cited
1999
Highly Cited
1999
Liarozole Acts Synergistically with 1α,25-Dihydroxyvitamin D3 to Inhibit Growth of DU 145 Human Prostate Cancer Cells by Blocking 24-Hydroxylase Activity.
1α,25-Dihydroxyvitamin D3[ 1,25-(OH)2D3] inhibits the proliferation of many cancer cells in culture, but not the aggressive human… 
Highly Cited
1994
Highly Cited
1994
Inhibition of the activity of ‘basic’ 5α-reductase (type 1) detected in DU 145 cells and expressed in insect cells
Highly Cited
1994
Highly Cited
1994
Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: evidence for an autocrine-inhibitory LHRH loop.
The therapeutic options for the treatment of androgen-independent prostatic cancers are rather limited; this is mainly because… 
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