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DP 178

Known as: DP-178, DP178 
National Institutes of Health

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enfuvirtide

Papers overview

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Highly Cited
2007
Highly Cited
2007
Demonstrating the C‐terminal boundary of the HIV 1 fusion conformation in a dynamic ongoing fusion process and implication for fusion inhibition
The core complex is a structure involved in the fusion mechanism of many viruses, as well as in intracellular vesicle fusion. A… 
2006
2006
Structurally Altered Peptides Reveal an Important Role for N-terminal Heptad Repeat Binding and Stability in the Inhibitory Action of HIV-1 Peptide DP178*
Human immunodeficiency virus 1 gp41 folds into a six-helix bundle whereby three C-terminal heptad repeat regions pack in an anti… 
2005
2005
The 2F5 epitope is helical in the HIV-1 entry inhibitor T-20.
The HIV-1 envelope glycoprotein gp41 is responsible for viral fusion with the host cell. The fusion process, as well as the full… 
2004
2004
Synthesis, conformation, and immunogenicity of monosaccharide-centered multivalent HIV-1 gp41 peptides containing the sequence of DP178.
2003
2003
How structure correlates to function for membrane associated HIV-1 gp41 constructs corresponding to the N-terminal half of the ectodomain.
2003
2003
ELDKWA-epitope-specific monoclonal antibodies inhibit HIV env-mediated syncytium formation.
Recent studies demonstrated that the N- and C-domains of HIV-1 gp41 are involved in virus-mediated membrane fusion resulting in… 
2002
2002
Conserved structures exposed in HIV-1 envelope glycoproteins stabilized by flexible linkers as potent entry inhibitors and potential immunogens.
The HIV-1 envelope glycoprotein (Env) undergoes conformational changes while driving entry. We hypothesized that some of the… 
2001
2001
SIV gp41 binds to membranes both in the monomeric and trimeric states: consequences for the neuropathology and inhibition of HIV infection.
The viral envelope glycoprotein gp41 mediates membrane fusion in HIV/SIV infection. gp41 ectodomain (e-gp41, residues 27-149… 
1998
1998
Quantitation of a 36-amino-acid peptide inhibitor of HIV-1 membrane fusion in animal and human plasma using high-performance liquid chromatography and fluorescence detection.
1998
1998
Capture of an early fusion-active conformation of HIV-1 gp41
Several typographical errors were introduced into the 178HA peptide sequence during printing. The sequence is the same as the DP… 
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