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enfuvirtide

Known as: peptide T20, Envelope polyprotein GP160 precursor [Contains: Exterior membrane glycoprotein,GP120, Transmembrane glycoprotein,GP41], enfuvirtide [Chemical/Ingredient] 
A short polypeptide with activity against human immunodeficiency virus (HIV). Enfuvirtide binds to the first heptad-repeat (HR1) in the gp41 viral… Expand
National Institutes of Health

Papers overview

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Review
2004
Review
2004
Highly active antiretroviral therapy (HAART) based on combinations of drugs that target key enzymes in the life-cycle of human… Expand
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Review
2004
Review
2004
Fusion inhibitors are a new class of antiretroviral drugs (ARVs) for the treatment of human immunodeficiency virus infection… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND The T-20 vs. Optimized Regimen Only Study 1 (TORO 1) was a randomized, open-label, phase 3 study of enfuvirtide (T-20… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND The T-20 vs. Optimized Regimen Only Study 2 (TORO 2) compared the efficacy and safety of 24 weeks of treatment with… Expand
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Highly Cited
2002
Highly Cited
2002
ABSTRACT The synthetic peptide T-20 (enfuvirtide) represents the first of a new class of antiretroviral compounds to demonstrate… Expand
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Highly Cited
2002
Highly Cited
2002
HIV entry inhibitors include coreceptor antagonists and the fusion inhibitor T-20. T-20 binds the first helical region (HR1) in… Expand
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Highly Cited
2000
Highly Cited
2000
ABSTRACT T-20 is a synthetic peptide that potently inhibits replication of human immunodeficiency virus type 1 by interfering… Expand
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Highly Cited
1999
Highly Cited
1999
The HIV-1 gp41 protein promotes viral entry by mediating the fusion of viral and cellular membranes. A prominent pocket on the… Expand
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Highly Cited
1998
Highly Cited
1998
T-20, a synthetic peptide corresponding to a region of the transmembrane subunit of the HIV-1 envelope protein, blocks cell… Expand
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Highly Cited
1996
Highly Cited
1996
The synthetic peptides DP-107 and DP-178 (T-20), derived from separate domains within the human immunodeficiency virus type 1… Expand
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