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DNA-dependent Protein Kinase Inhibitor VX-984

Known as: DNA-PK Inhibitor VX-984, VX-984, VX984 
An ATP-competitive inhibitor of the catalytic subunit of DNA-dependent protein kinase (DNA-PK), with potential sensitizing and enhancing activities… Expand
National Institutes of Health

Papers overview

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2018
2018
Radiotherapy is a primary treatment modality for glioblastomas (GBM). Because DNA-PKcs is a critical factor in the repair of… Expand
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2018
2018
Purpose DNA double-strand breaks (DSBs) can be repaired by non-homologous end joining (NHEJ) or homologous recombination (HR). We… Expand
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Review
2017
Review
2017
The catalytic activity of DNA‐dependent protein kinase (DNA‐PK) is critical to its ability to repair lethal DNA double‐strand… Expand
2017
2017
Background: The efficacy of chemotherapeutic agents such as doxorubicin, which cause lethal DNA double-strand breaks (DSBs), is… Expand
2017
2017
  • Nature Biotechnology
  • 2017
  • Corpus ID: 3612679
Vertex Pharmaceuticals, the Boston-based biotech known for developing novel cystic fibrosis drugs, has licensed four R&D cancer… Expand
2016
2016
Ionizing radiation (IR), which is widely used for the treatment of cancer, causes double-strand breaks (DSBs) in DNA. If left… Expand