DNA-dependent Protein Kinase Inhibitor VX-984
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Radiotherapy is a primary treatment modality for glioblastomas (GBM). Because DNA-PKcs is a critical factor in the repair of… Expand Purpose DNA double-strand breaks (DSBs) can be repaired by non-homologous end joining (NHEJ) or homologous recombination (HR). We… Expand The catalytic activity of DNA‐dependent protein kinase (DNA‐PK) is critical to its ability to repair lethal DNA double‐strand… Expand Background: The efficacy of chemotherapeutic agents such as doxorubicin, which cause lethal DNA double-strand breaks (DSBs), is… Expand Vertex Pharmaceuticals, the Boston-based biotech known for developing novel cystic fibrosis drugs, has licensed four R&D cancer… Expand Ionizing radiation (IR), which is widely used for the treatment of cancer, causes double-strand breaks (DSBs) in DNA. If left… Expand