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DNA-dependent Protein Kinase Inhibitor VX-984

Known as: DNA-PK Inhibitor VX-984, VX-984, VX984 
An ATP-competitive inhibitor of the catalytic subunit of DNA-dependent protein kinase (DNA-PK), with potential sensitizing and enhancing activities… 
National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
Radiotherapy is a primary treatment modality for glioblastomas (GBM). Because DNA-PKcs is a critical factor in the repair of… 
2018
2018
Purpose DNA double-strand breaks (DSBs) can be repaired by non-homologous end joining (NHEJ) or homologous recombination (HR). We… 
Review
2017
Review
2017
The catalytic activity of DNA‐dependent protein kinase (DNA‐PK) is critical to its ability to repair lethal DNA double‐strand… 
2017
2017
Background: The efficacy of chemotherapeutic agents such as doxorubicin, which cause lethal DNA double-strand breaks (DSBs), is… 
2017
2017
  • Nature Biotechnology
  • 2017
  • Corpus ID: 3612679
Vertex Pharmaceuticals, the Boston-based biotech known for developing novel cystic fibrosis drugs, has licensed four R&D cancer… 
2016
2016
Ionizing radiation (IR), which is widely used for the treatment of cancer, causes double-strand breaks (DSBs) in DNA. If left…