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99mTc-Labeled Small-Molecule Inhibitors of Prostate-Specific Membrane Antigen for Molecular Imaging of Prostate Cancer
These 99mTc-labeled radiopharmaceuticals targeting PSMA may provide a SPECT molecular imaging option to assist in the initial diagnosis of prostate cancer and the management of patient care by monitoring disease progression. Expand
Preclinical evaluation of an 131I-labeled benzamide for targeted radiotherapy of metastatic melanoma.
The melanin-specific binding of [(131)I]MIP-1145 combined with prolonged tumor retention, the ability to significantly inhibit tumor growth, and acceptable projected human dosimetry suggest that it may be effective as a radiotherapeutic pharmaceutical for treating patients with metastatic malignant melanoma. Expand
Preclinical evaluation of novel glutamate-urea-lysine analogues that target prostate-specific membrane antigen as molecular imaging pharmaceuticals for prostate cancer.
Specific binding to PSMA in vivo was shown by competition with PMPA in LNCaP xenografts, and the absence of uptake in PC3 xenografteds. Expand
Disruption of gene expression and induction of apoptosis in prostate cancer cells by a DNA-damaging agent tethered to an androgen receptor ligand.
11beta-dichloro induces a unique pattern of gene disruption, induces apoptosis in apoptosis-resistant cells, and shows promising anticancer activity in animals. Expand
A series of halogenated heterodimeric inhibitors of prostate specific membrane antigen (PSMA) as radiolabeled probes for targeting prostate cancer.
- K. Maresca, S. Hillier, +8 authors J. Babich
- Chemistry, Medicine
- Journal of medicinal chemistry
- 22 January 2009
Two lead iodine compounds were radiolabeled with (123)I and (131)Iand demonstrated specific PSMA binding on human prostate cancer cells, warranting evaluation as radioligands for the detection, staging, and monitoring of prostate cancer. Expand
A rationally designed genotoxin that selectively destroys estrogen receptor-positive breast cancer cells.
- K. Mitra, J. Marquis, +5 authors R. G. Croy
- Chemistry, Medicine
- Journal of the American Chemical Society
- 6 March 2002
The synthesis of a bifunctional compound consisting of an aniline mustard linked to the 7alpha position of estradiol that can form covalent DNA adducts that have high affinity for the estrogen receptor showed increased sensitivity to the cytotoxic effects of the new compound. Expand
123I-MIP-1072, a Small-Molecule Inhibitor of Prostate-Specific Membrane Antigen, Is Effective at Monitoring Tumor Response to Taxane Therapy
The high specificity of 123I-MIP-1072 for prostate cancer may allow monitoring of tumor progression in patients before, during, and after chemotherapy. Expand
Comparison of high-specific-activity ultratrace 123/131I-MIBG and carrier-added 123/131I-MIBG on efficacy, pharmacokinetics, and tissue distribution.
- J. Barrett, J. Joyal, +6 authors J. Babich
- Cancer biotherapy & radiopharmaceuticals
- 25 June 2010
Care must be taken when administering therapeutic doses of the current carrier-added (131)I-MIBG because of its potential to cause adverse cardiovascular side-effects, nausea, and vomiting and the increased uptake and retention of Ultratrace (123/131)i-MI BG may translate into a superior diagnostic and therapeutic potential. Expand
Metabolic response of lung cancer cells to radiation in a paper-based 3D cell culture system.
This system can capture some aspects of radiosensitivity of populations of cancer cells related to mass-transport phenomenon, carry out systematic studies of radiation response in vitro that decouple effects from migration and proliferation of cells, and regulate the exposure of oxygen to subpopulations of cells in a tissue-like construct either before or after irradiation. Expand
Synthesis and Evaluation of a Series of 99mTc(CO)3+ Lisinopril Complexes for In Vivo Imaging of Angiotensin-Converting Enzyme Expression
High-affinity 99mTc-labeled ACE inhibitor has been designed with potency similar to that of lisinopril and has been demonstrated to specifically localize to tissues that express ACE in vivo, supporting ACE-mediated binding in vivo. Expand