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DNA Minor Groove Binding

DNA Minor Groove Binding involves temporary non-covalent interaction through intermolecular physical forces of attraction by a protein or low… Expand
National Institutes of Health

Papers overview

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2010
2010
Eight indole derivatives were studied for their DNA binding ability using fluorescence quenching and molecular docking methods… Expand
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Highly Cited
2007
Highly Cited
2007
The classical model of DNA minor groove binding compounds is that they should have a crescent shape that closely fits the helical… Expand
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Highly Cited
2002
Highly Cited
2002
The synthesis of 1,3-bis-[3,4,5,6-tetrahydroxyazepane-N-p-phenoxy] and 1,3-bis-[3,4,5,6-tetrahydroxyazepane-N-p-benzyloxy… Expand
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2002
2002
DNA minor groove binder hybrid molecules, netropsin derivatives such as N-[2-(dimethylamino)ethyl]-1-methyl-4-aminopyrrolo-2… Expand
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2001
2001
The poly(ADP-ribose) polymerase (PARP) is involved in cell recovery from DNA damage, such as methylation of N3-adenine, that… Expand
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Highly Cited
2000
Highly Cited
2000
Maintenance of genomic integrity is vital to all organisms. A number of human genetic disorders, including Werner Syndrome, Bloom… Expand
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Highly Cited
1993
Highly Cited
1993
A series of bis(amidinobenzimidazoles) and bis(amidinoindoles) with varied linking chains connecting the aromatic groups and… Expand
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1993
1993
The design, synthesis, and evaluation of DNA minor groove binding agents related to (+)-CC-1065 and (+)-duocarmycin A are… Expand
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Highly Cited
1989
Highly Cited
1989
The effects of distamycin, Hoechst 33258, and 4',6-diamidine-2-phenylindole (DAPI) on the catalytic activity of topoisomerase II… Expand
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Highly Cited
1989
Highly Cited
1989
This study demonstrated that agents capable of interacting with the minor groove in nuclear DNA interfere with topoisomerase II… Expand
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