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DNA Minor Groove Binding

DNA Minor Groove Binding involves temporary non-covalent interaction through intermolecular physical forces of attraction by a protein or low… 
National Institutes of Health

Papers overview

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2010
2010
Effects of DNA minor groove binding agents on global gene expression.
The capacity of two minor groove binding agents that differ in their DNA sequence selectivity to modulate gene expression in… 
2009
2009
Evaluation of molecular modelling methods to predict the sequence-selectivity of DNA minor groove binding ligands.
The accurate prediction of ligand-receptor interaction energies by molecular modelling methods remains challenging. Predicting… 
2004
2004
A novel assay to determine the sequence preference and affinity of DNA minor groove binding compounds.
Sequence-specific binding in the minor groove of DNA by small molecules is a growing area of research with possible therapeutic… 
2001
2001
Poly (ADP-ribose) polymerase inhibitor increases apoptosis and reduces necrosis induced by a DNA minor groove binding methyl sulfonate ester
The poly(ADP-ribose) polymerase (PARP) is involved in cell recovery from DNA damage, such as methylation of N3-adenine, that… 
1998
1998
DNA minor groove binding-directed poisoning of human DNA topoisomerase I by terbenzimidazoles.
We have employed a broad range of spectroscopic, calorimetric, DNA cleavage, and DNA winding/unwinding measurements to… 
Review
1997
Review
1997
DNA minor groove binding ligands: a new class of anticancer agents.
This paper gives an overview of the available pharmacological and clinical data of a new class of anticancer drugs which act by… 
1996
1996
Bisindolylmaleimides linked to DNA minor groove binding lexitropsins: synthesis, inhibitory activity against topoisomerase I, and biological evaluation.
The synthesis, characterization, inhibitory activity against topoisomerase I, and biological evaluation of a series of… 
1994
1994
Design, synthesis, and evaluation of DNA minor groove binding agents: the duocarmycins
Abstract 
1993
1993
Design, synthesis, and evaluation of DNA minor groove binding agents
Abstract 
Highly Cited
1989
Highly Cited
1989
DNA minor groove binding agents interfere with topoisomerase II mediated lesions induced by epipodophyllotoxin derivative VM-26 and acridine derivative m-AMSA in nuclei from L1210 cells.
This study demonstrated that agents capable of interacting with the minor groove in nuclear DNA interfere with topoisomerase II… 
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