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DLST wt Allele

Known as: Alpha-Ketoglutarate Dehydrogenase Complex, E2 Component of Gene, DLTS, Dihydrolipoamide S-Succinyltransferase (E2 Component of 2-Oxo-Glutarate Complex) wt Allele 
Human DLST wild-type allele is located in the vicinity of 14q24.3 and is approximately 22 kb in length. This allele, which encodes… 
National Institutes of Health

Related topics

Related topics

4 relations
14q24.3Catabolic ProcessCell RespirationCitrate Cycle (TCA Cycle) Pathway

Papers overview

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Highly Cited
2016
Highly Cited
2016
Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: a dose-escalation, open-label, pharmacokinetic, phase 1 study.
Highly Cited
2014
Highly Cited
2014
A Phase Ib Dose-Escalation Study of the Oral Pan-PI3K Inhibitor Buparlisib (BKM120) in Combination with the Oral MEK1/2 Inhibitor Trametinib (GSK1120212) in Patients with Selected Advanced Solid…
Purpose: MAPK and PI3K/AKT/mTOR pathways play important roles in many tumors. In this study, safety, antitumor activity, and… 
Highly Cited
2013
Highly Cited
2013
CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): a single-arm, open-label, phase 1-2 study.
Highly Cited
2012
Highly Cited
2012
A Phase I Combination Study of Olaparib with Cisplatin and Gemcitabine in Adults with Solid Tumors
Purpose: To determine the safety and tolerability of olaparib with cisplatin and gemcitabine, establish the maximum tolerated… 
Highly Cited
2010
Highly Cited
2010
Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab.
PURPOSE To determine the recommended dose of everolimus, a mammalian target of rapamycin inhibitor, combined with paclitaxel and… 
Highly Cited
2001
Highly Cited
2001
Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms.
PURPOSE To define the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of the novel protein kinase inhibitor, UCN-01… 
Highly Cited
2000
Highly Cited
2000
Phase I trial of twice-weekly intravenous interleukin 12 in patients with metastatic renal cell cancer or malignant melanoma: ability to maintain IFN-gamma induction is associated with clinical…
The aim of this study was to examine the tolerability, antitumor activity, and biological effects of a new schedule of i.v… 
Highly Cited
1999
Highly Cited
1999
Clinical and pharmacokinetic phase I study of multitargeted antifolate (LY231514) in combination with cisplatin.
PURPOSE Multitargeted antifolate (MTA; LY231514) has broad preclinical antitumor activity and inhibits a variety of intracellular… 
Highly Cited
1985
Highly Cited
1985
Electrical properties of dislocations and point defects in plastically deformed silicon.
Energy levels of defect states introduced by plastic deformation of n-type silicon have been studied by capacitance transient… 
Highly Cited
1977
Highly Cited
1977
Double correlation technique (DDLTS) for the analysis of deep level profiles in semiconductors
A very sensitive technique is presented which can be applied to determine deep level profiles in space-charge layers of Schottky… 
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