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Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.
A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell model for tumor development and progression. The meeting participants were charged with evaluating data suggestingExpand
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Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML.
BACKGROUND The progression of chronic myelogenous leukemia (CML) to blast crisis is supported by self-renewing leukemic stem cells. In normal mouse hematopoietic stem cells, the process ofExpand
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Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
Leukemia can be viewed as a newly formed, abnormal hematopoietic tissue initiated by a few leukemic stem cells (LSCs) that undergo an aberrant and poorly regulated process of organogenesis analogousExpand
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Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
Although the role of Hedgehog (Hh) signalling in embryonic pattern formation is well established, its functions in adult tissue renewal and maintenance remain unclear, and the relationship of theseExpand
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CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis
Macrophages clear pathogens and damaged or aged cells from the blood stream via phagocytosis. Cell-surface CD47 interacts with its receptor on macrophages, SIRPalpha, to inhibit phagocytosis ofExpand
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Stems Cells and the Pathways to Aging and Cancer
The aging of tissue-specific stem cell and progenitor cell compartments is believed to be central to the decline of tissue and organ integrity and function in the elderly. Here, we examine evidenceExpand
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Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
This corrects the article DOI: 10.1038/nature07737
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Chronic myeloid leukemia: mechanisms of blastic transformation.
The BCR-ABL1 oncoprotein transforms pluripotent HSCs and initiates chronic myeloid leukemia (CML). Patients with early phase (also known as chronic phase [CP]) disease usually respond to treatmentExpand
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Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis.
PURPOSE Myelofibrosis is a myeloid malignancy associated with anemia, splenomegaly, and constitutional symptoms. Patients frequently harbor JAK-STAT activating mutations that are sensitive toExpand
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Glycogen synthase kinase 3β missplicing contributes to leukemia stem cell generation
Recent evidence suggests that a rare population of self-renewing cancer stem cells (CSC) is responsible for cancer progression and therapeutic resistance. Chronic myeloid leukemia (CML) represents anExpand
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