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DKK2 gene

Known as: DKK2, DICKKOPF, XENOPUS, HOMOLOG OF, 2, dickkopf WNT signaling pathway inhibitor 2 
This gene plays a role in the regulation of Wnt signaling.
National Institutes of Health

Related topics

Related topics

5 relations
DKK1 geneDickkopf-Related Protein 2Intercellular Communication ProcessSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
DKK2 blockage-mediated immunotherapy enhances anti-angiogenic therapy of Kras mutated colorectal cancer
2020
2020
Rational design of peptides for identification of linear epitopes and generation of neutralizing monoclonal antibodies against DKK2 for cancer therapy
Abstract Dickkopf-related protein 2 (DKK2)is a member of the Dickkopf family in Wnt signaling pathway. Recently, we found that… 
2018
2018
In silico studying of the whole protein structure and dynamics of Dickkopf family members showed that N-terminal domain of Dickkopf 2 in contrary to other Dickkopfs facilitates its interaction with…
Abstract Wnt (Wingless Int) signaling pathway has been known to be dysregulated in several human cancers, especially colorectal… 
2017
2017
Concurrent Hypermethylation of SFRP2 and DKK2 Activates the Wnt/β-Catenin Pathway and Is Associated with Poor Prognosis in Patients with Gastric Cancer
Aberrant hypermethylation of Wnt antagonists has been observed in gastric cancer. A number of studies have focused on the… 
2016
2016
miR-187-5p Regulates Cell Growth and Apoptosis in Acute Lymphoblastic Leukemia via DKK2
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and causes a high rate of mortality in affected adults… 
Review
2014
Review
2014
Dysregulated expression of dickkopfs for potential detection of hepatocellular carcinoma
The prognosis for hepatocellular carcinoma (HCC) remains dismal due to the lack of diagnostic markers for early detection. This… 
2014
2014
Rheumatoid Arthritis Bone Fragility Is Associated With Upregulation of IL17 and DKK1 Gene Expression
Our aim was to compare bone gene expression in rheumatoid arthritis (RA) and primary osteoporosis (OP) patients. Secondary aims… 
2011
2011
Transition from cylindroma to spiradenoma in CYLD‐defective tumours is associated with reduced DKK2 expression
Patients carrying heterozygous germline truncating mutations in the CYLD gene develop multiple primary hair follicle‐related… 
2010
2010
A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Studies of alcohol dependence (AD) have consistently found evidence of linkage on chromosome 4q21-q32. A genome-wide linkage scan… 
2009
2009
EWS/ETS Regulates the Expression of the Dickkopf Family in Ewing Family Tumor Cells
Background The Dickkopf (DKK) family comprises a set of proteins that function as regulators of Wnt/β–catenin signaling and has a… 
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