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DKK2 gene
Known as:
DKK2
, DICKKOPF, XENOPUS, HOMOLOG OF, 2
, dickkopf WNT signaling pathway inhibitor 2
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This gene plays a role in the regulation of Wnt signaling.
National Institutes of Health
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Related topics
Related topics
5 relations
DKK1 gene
Dickkopf-Related Protein 2
Intercellular Communication Process
Signal Transduction
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
DKK2 blockage-mediated immunotherapy enhances anti-angiogenic therapy of Kras mutated colorectal cancer
Jiajia Hu
,
Zhengting Wang
,
+10 authors
Qian Xiao
Biomedicine & pharmacotherapy = Biomedecine…
2020
Corpus ID: 219480210
2020
2020
Rational design of peptides for identification of linear epitopes and generation of neutralizing monoclonal antibodies against DKK2 for cancer therapy
Rongqing Zhao
,
Qian Xiao
,
+7 authors
Le Sun
Antibody Therapeutics
2020
Corpus ID: 218585241
Abstract Dickkopf-related protein 2 (DKK2)is a member of the Dickkopf family in Wnt signaling pathway. Recently, we found that…
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2018
2018
In silico studying of the whole protein structure and dynamics of Dickkopf family members showed that N-terminal domain of Dickkopf 2 in contrary to other Dickkopfs facilitates its interaction with…
S. Sadeghi
,
Mansour Poorebrahim
,
+4 authors
L. Teimoori-Toolabi
Journal of Biomolecular Structure and Dynamics
2018
Corpus ID: 51707118
Abstract Wnt (Wingless Int) signaling pathway has been known to be dysregulated in several human cancers, especially colorectal…
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2017
2017
Concurrent Hypermethylation of SFRP2 and DKK2 Activates the Wnt/β-Catenin Pathway and Is Associated with Poor Prognosis in Patients with Gastric Cancer
Hao Wang
,
Xianglong Duan
,
+4 authors
Penggao Dai
Molecules and Cells
2017
Corpus ID: 237623
Aberrant hypermethylation of Wnt antagonists has been observed in gastric cancer. A number of studies have focused on the…
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2016
2016
miR-187-5p Regulates Cell Growth and Apoptosis in Acute Lymphoblastic Leukemia via DKK2
Ye Lou
,
Lei Liu
,
L. Zhan
,
Xuewei Wang
,
H. Fan
Oncology Research
2016
Corpus ID: 45660136
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and causes a high rate of mortality in affected adults…
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Review
2014
Review
2014
Dysregulated expression of dickkopfs for potential detection of hepatocellular carcinoma
S. Fatima
,
J. Luk
,
R. Poon
,
N. P. Lee
Expert Review of Molecular Diagnostics
2014
Corpus ID: 27362260
The prognosis for hepatocellular carcinoma (HCC) remains dismal due to the lack of diagnostic markers for early detection. This…
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2014
2014
Rheumatoid Arthritis Bone Fragility Is Associated With Upregulation of IL17 and DKK1 Gene Expression
J. Caetano-Lopes
,
A. Rodrigues
,
+10 authors
J. Fonseca
Clinical reviews in allergy and immunology
2014
Corpus ID: 16833555
Our aim was to compare bone gene expression in rheumatoid arthritis (RA) and primary osteoporosis (OP) patients. Secondary aims…
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2011
2011
Transition from cylindroma to spiradenoma in CYLD‐defective tumours is associated with reduced DKK2 expression
N. Rajan
,
J. Burn
,
J. Langtry
,
M. Sieber-Blum
,
C. Lord
,
A. Ashworth
Journal of Pathology
2011
Corpus ID: 5270819
Patients carrying heterozygous germline truncating mutations in the CYLD gene develop multiple primary hair follicle‐related…
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2010
2010
A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
G. Kalsi
,
Po-Hsiu Kuo
,
+16 authors
B. Riley
Human Molecular Genetics
2010
Corpus ID: 7261185
Studies of alcohol dependence (AD) have consistently found evidence of linkage on chromosome 4q21-q32. A genome-wide linkage scan…
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2009
2009
EWS/ETS Regulates the Expression of the Dickkopf Family in Ewing Family Tumor Cells
Yoshitaka Miyagawa
,
H. Okita
,
+6 authors
N. Kiyokawa
PLoS ONE
2009
Corpus ID: 10154632
Background The Dickkopf (DKK) family comprises a set of proteins that function as regulators of Wnt/β–catenin signaling and has a…
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