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DISC1 gene

Known as: DISC1, DISRUPTED IN SCHIZOPHRENIA 1 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
TDP-43 and DISC1 Co-Aggregation Disrupts Dendritic Local Translation and Mental Function in FTLD
BACKGROUND— Neurodegenerative diseases involving protein aggregation often accompany psychiatric symptoms. Frontotemporal lobar… 
2017
2017
A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related…
Disrupted in Schizophrenia 1 (DISC1) is a scaffolding protein of significant importance for neurodevelopment and a prominent… 
2016
2016
Cloning of the promoter of NDE1, a gene implicated in psychiatric and neurodevelopmental disorders through copy number variation
2015
2015
DISC1-mediated dysregulation of adult hippocampal neurogenesis in rats
Adult hippocampal neurogenesis, the constitutive generation of new granule cells in the dentate gyrus of the mature brain, is a… 
2014
2014
The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects
2012
2012
DISC1 and Striatal Volume: A Potential Risk Phenotype For mental Illness
Disrupted-in-schizophrenia 1 was originally discovered in a large Scottish family with abnormally high rates of severe mental… 
Review
2011
Review
2011
Regulation of the cytoskeleton by Disrupted-in-Schizophrenia 1 (DISC1)
2008
2008
DISC1 mRNA expression is not influenced by common Cis‐acting regulatory polymorphisms or imprinting
The hypothesis that genetic variation in Disrupted in Schizophrenia 1 (DISC1) influences risk of schizophrenia and other major… 
Highly Cited
2007
Highly Cited
2007
DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1.
Disrupted-In-Schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. DISC1 is reported to interact with… 
Review
2006
Review
2006
Deletion Polymorphism of Disc1 Is Common to All 129 Mouse Substrains: Implications for Gene-Targeting Studies of Brain Function
We report that the Disc1 gene in all extant 129 mouse inbred substrains has a deletion, previously considered specific to the… 
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