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DIRAS3 gene

Known as: NOEY2, DIRAS Family, GTP-Binding RAS-Like 3 Gene, DIRAS family GTP binding RAS like 3 
This gene plays a role in signal transduction and suppression of cell growth.
National Institutes of Health

Related topics

Related topics

7 relations
ARHI protein, humanDIRAS1 geneHomo sapiensSignal Transduction

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DIRAS3 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Estimation of Additive, Dominance, and Imprinting Genetic Variance Using Genomic Data
Traditionally, exploration of genetic variance in humans, plants, and livestock species has been limited mostly to the use of… 
Highly Cited
2014
Highly Cited
2014
DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells
DIRAS3 is an imprinted tumor suppressor gene that is downregulated in 60% of human ovarian cancers. Re-expression of DIRAS3 at… 
Highly Cited
2014
Highly Cited
2014
ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of…
The process of autophagy has been described in detail at the molecular level in normal cells, but less is known of its regulation… 
Highly Cited
2012
Highly Cited
2012
The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways
Ovarian cancers migrate and metastasize over the surface of the peritoneal cavity. Consequently, dysregulation of mechanisms that… 
Highly Cited
2010
Highly Cited
2010
EBV transformation and cell culturing destabilizes DNA methylation in human lymphoblastoid cell lines.
Review
2009
Review
2009
Characterization of Conserved and Nonconserved Imprinted Genes in Swine1
To increase our understanding of imprinted genes in swine, we carried out a comprehensive analysis of this gene family using two… 
Review
2006
Review
2006
Genetic instability in human tumors.
Genetic, or genomic, instability refers to a series of observed spontaneous genetic changes occurring at an accelerated rate in… 
Highly Cited
2004
Highly Cited
2004
Meningiomas May Be a Component Tumor of Multiple Endocrine Neoplasia Type 1
Purpose: Recently, an increased incidence of some nonendocrine tumors are reported in patients with multiple endocrine neoplasia… 
Highly Cited
2003
Highly Cited
2003
Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers.
ARHI is a maternally imprinted tumor suppressor gene that maps to a site on chromosome 1p31 where loss of heterozygosity has been… 
Highly Cited
2002
Highly Cited
2002
Rig is a novel Ras-related protein and potential neural tumor suppressor
The Ras superfamily consists of a large group of monomeric GTPases demonstrating homology to Ras oncoproteins. Although… 
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