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DIRAS3 gene

Known as: NOEY2, DIRAS Family, GTP-Binding RAS-Like 3 Gene, DIRAS family GTP binding RAS like 3 
This gene plays a role in signal transduction and suppression of cell growth.
National Institutes of Health

Related topics

Related topics

7 relations
ARHI protein, humanDIRAS1 geneHomo sapiensSignal Transduction

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DIRAS3 wt Allele

Papers overview

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2019
2019
Uniparental isodisomy of chromosome 1 results in glycogen storage disease type III with profound growth retardation
Glycogen storage disease type III (GSDIII) is caused by mutations of AGL gene with debranching enzyme deficiency. Patients with… 
2017
2017
DNA methyltransferase inhibitors influence on the DIRAS3 and STAT3 expression and in vitro migration of ovarian and breast cancer cells.
OBJECTIVES Downregulation of DIRAS3 (DIRAS family, GTP-binding Ras-like 3) is related to ovarian and breast cancer progression. A… 
2015
2015
Estimation of Additive, Dominance, and Imprinting Genetic Variance Using Genomic Data
Traditionally, exploration of genetic variance in humans, plants, and livestock species has been limited mostly to the use of… 
2013
2013
The tumor suppressor gene ARHI (DIRAS3) inhibits ovarian cancer cell migration through multiple mechanisms
ARHI is an imprinted tumor suppressor gene that is downregulated in > 60% of ovarian cancers, associated with decreased… 
2013
2013
The tumour suppressor DiRas3 interacts with C‐RAF and downregulates MEK activity to restrict cell migration
The mitogenic pathway, composed of RAF kinases, mitogen‐activated protein kinase kinases (MEK) and extracellular signal‐regulated… 
2012
2012
The Tumor Suppressor DiRas3 Forms a Complex with H-Ras and C-RAF Proteins and Regulates Localization, Dimerization, and Kinase Activity of C-RAF*
Background: The tumor suppressor DiRas3 interferes with the Ras/MAPK mitogenic cascade. Results: DiRas3 associates with H-Ras and… 
2010
2010
Imprinted tumor suppressor gene ARHI induces apoptosis correlated with changes in DNA methylation in pancreatic cancer cells.
Aplesia Ras homologue member I (ARHI, DIRAS3) is a Ras-related imprinted growth inhibitory gene whose expression is down… 
2009
2009
ARHI (DIRAS3), an imprinted tumour suppressor gene, binds to importins and blocks nuclear import of cargo proteins.
ARHI (aplasia Ras homologue member I; also known as DIRAS3) is an imprinted tumour suppressor gene, the expression of which is… 
2005
2005
Promoter methylation and mRNA expression of NOEY2 gene in the development of breast cancers
Purpose To investigate the methylation status of NOEY2 gene promoter and its effects for expression of mRNA in breast cancer… 
2002
2002
ARHI/NOEY2 Inactivation May Be Important in Breast Tumor Pathogenesis
Allelic loss frequently occurs on the short arm of chromosome 1 in human breast carcinoma, suggesting that the ARHI/NOEY2 gene… 
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