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DIO2 gene

Known as: DIO2, D2, deiodinase-2 
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Thyroid disruption in zebrafish (Danio rerio) larvae: Different molecular response patterns lead to impaired eye development and visual functions.
Highly Cited
2012
Highly Cited
2012
Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae.
Highly Cited
2012
Highly Cited
2012
Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass
BackgroundLaparoscopic Roux-en-Y gastric bypass (RYGB) induces a more favorable metabolic profile than expected by weight loss… 
Review
2011
Review
2011
Type 2 deiodinase at the crossroads of thyroid hormone action.
Review
2011
Review
2011
Deiodinases: the balance of thyroid hormone: local control of thyroid hormone action: role of type 2 deiodinase.
The thyroid gland predominantly secretes the pro-hormone thyroxine (T(4)) that is converted to the active hormone 3,5,3'-l… 
Highly Cited
2011
Highly Cited
2011
Tissue-specific thyroid hormone regulation of gene transcripts encoding iodothyronine deiodinases and thyroid hormone receptors in striped parrotfish (Scarus iseri).
Highly Cited
2008
Highly Cited
2008
Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis.
Osteoarthritis [MIM 165720] is a common late-onset articular joint disease for which no pharmaceutical intervention is available… 
Highly Cited
2006
Highly Cited
2006
Melatonin regulates type 2 deiodinase gene expression in the Syrian hamster.
In seasonal species, photoperiod organizes various physiological processes, including reproduction. Recent data indicate that the… 
Highly Cited
2005
Highly Cited
2005
Mutations in SECISBP2 result in abnormal thyroid hormone metabolism
Incorporation of selenocysteine (Sec), through recoding of the UGA stop codon, creates a unique class of proteins. Mice lacking… 
Highly Cited
2002
Highly Cited
2002
Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor.
Thyroid hormone action is an important determinant of energy and glucose metabolism. T4 metabolism is regulated by the… 
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