New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
- J. Dupuis, C. Langenberg, I. Barroso
- Medicine, BiologyNature Genetics
- 17 January 2010
It is demonstrated that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- A. Morris, B. Voight, M. McCarthy
- BiologyNature Genetics
- 26 July 2012
A meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, finds a long tail of additional common variant loci explaining much of the variation in susceptibility to type 2 diabetes.
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
- B. Voight, L. Scott, M. McCarthy
- BiologyNature Genetics
- 1 July 2010
By combining genome-wide association data from 8,130 individuals with type 2 diabetes and 38,987 controls of European descent and following up previously unidentified meta-analysis signals, 12 new T2D association signals are identified with combined P < 5 × 10−8.
Common genetic determinants of vitamin D insufficiency: a genome-wide association study
- Thomas J. Wang, Feng Zhang, T. Spector
- Medicine, BiologyThe Lancet
- 17 July 2010
Statistical methods for mapping quantitative trait loci from a dense set of markers.
- J. Dupuis, D. Siegmund
- EconomicsGenetics
- 1999
It is shown that with an appropriate evaluation of the coverage probability a support region is approximately a confidence region, and a theroretical explanation of the empirical observation that the size of the support regions is proportional to the sample size, not the square root of the samplesize, as one might expect from standard statistical theory.
Common variants at 30 loci contribute to polygenic dyslipidemia
- S. Kathiresan, C. Willer, L. Cupples
- MedicineNature Genetics
- 2009
The results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia.
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
- A. Mahajan, D. Taliun, M. McCarthy
- BiologyNature Genetics
- 8 October 2018
Combining 32 genome-wide association studies with high-density imputation provides a comprehensive view of the genetic contribution to type 2 diabetes in individuals of European ancestry with respect to locus discovery, causal-variant resolution, and mechanistic insight.
Genotype score in addition to common risk factors for prediction of type 2 diabetes.
- J. Meigs, P. Shrader, L. Cupples
- MedicineNew England Journal of Medicine
- 20 November 2008
A genotype score based on 18 risk alleles predicted new cases of diabetes in the community but provided only a slightly better prediction of risk than knowledge of common risk factors alone.
Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts
- K. S. Vimaleswaran, D. Berry, E. Hyppönen
- MedicinePLoS Medicine
- 1 February 2013
A mendelian randomization study based on data from multiple cohorts conducted by Karani Santhanakrishnan Vimaleswaran and colleagues re-examines the causal nature of the relationship between vitamin…
Identifying SNPs predictive of phenotype using random forests
- A. Bureau, J. Dupuis, P. van Eerdewegh
- BiologyGenetic Epidemiology
- 1 February 2005
This work extends the concept of importance to pairs of predictors, to capture joint effects, and explores the behavior of importance measures over a range of two‐locus disease models in the presence of a varying number of SNPs unassociated with the phenotype.
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