Author pages are created from data sourced from our academic publisher partnerships and public sources.
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting… Expand
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and… Expand
Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter.
In a prospective cross-sectional study, we used computerized volumetry of magnetic resonance images to examine the patterns of brain aging in 148 healthy volunteers. The most substantial age-related… Expand
Statistical methods for mapping quantitative trait loci from a dense set of markers.
Lander and Botstein introduced statistical methods for searching an entire genome for quantitative trait loci (QTL) in experimental organisms, with emphasis on a backcross design and QTL having only… Expand
Common variants at 30 loci contribute to polygenic dyslipidemia
Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic basis of… Expand
Poor Performance of Bootstrap Confidence Intervals for the Location of a Quantitative Trait Locus
The aim of many genetic studies is to locate the genomic regions (called quantitative trait loci, QTL) that contribute to variation in a quantitative trait (such as body weight). Confidence intervals… Expand
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the… Expand
Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts
- K. S. Vimaleswaran, Diane J. Berry, +55 authors E. Hyppönen
- Medicine, Geography
- PLoS medicine
- 1 February 2013
A mendelian randomization study based on data from multiple cohorts conducted by Karani Santhanakrishnan Vimaleswaran and colleagues re-examines the causal nature of the relationship between vitamin… Expand
A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait.
- R. Little, J. Carulli, +32 authors M. Johnson
- Biology, Medicine
- American journal of human genetics
Osteoporosis is a complex disease that affects >10 million people in the United States and results in 1.5 million fractures annually. In addition, the high prevalence of osteopenia (low bone mass) in… Expand
Identifying SNPs predictive of phenotype using random forests
- A. Bureau, J. Dupuis, +4 authors P. Van Eerdewegh
- Medicine, Biology
- Genetic epidemiology
- 1 February 2005
There has been a great interest and a few successes in the identification of complex disease susceptibility genes in recent years. Association studies, where a large number of single‐nucleotide… Expand