FAQ

DGAT2 gene

Known as: ACYL-CoA:DIACYLGLYCEROL ACYLTRANSFERASE 2, DGAT2, DIACYLGLYCEROL O-ACYLTRANSFERASE 2 
 

Topic mentions per year

Topic mentions per year

2001-2017
0102020012017

Papers overview

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2010
2010
DGAT1, DGAT2 and PDAT Expression in Seeds and Other Tissues of Epoxy and Hydroxy Fatty Acid Accumulating Plants
Triacylglycerol (TAG) is the main storage lipid in plants. Acyl-CoA: diacylglycerol acyltransferase (DGAT1 and DGAT2) and… (More)
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Highly Cited
2009
Highly Cited
2009
The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria.
The synthesis and storage of neutral lipids in lipid droplets is a fundamental property of eukaryotic cells, but the spatial… (More)
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Highly Cited
2006
Highly Cited
2006
Tung tree DGAT1 and DGAT2 have nonredundant functions in triacylglycerol biosynthesis and are localized to different subdomains of the endoplasmic reticulum.
Seeds of the tung tree (Vernicia fordii) produce large quantities of triacylglycerols (TAGs) containing approximately 80… (More)
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Highly Cited
2006
Highly Cited
2006
Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis.
Stearoyl-coenzyme A desaturase (SCD) is an endoplasmic reticulum (ER) protein that catalyzes the Delta9-cis desaturation of… (More)
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Highly Cited
2006
Highly Cited
2006
Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2.
Triacylglycerols are the predominant molecules of energy storage in eukaryotes. However, excessive accumulation of… (More)
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Highly Cited
2005
Highly Cited
2005
Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice.
In this study, we investigated the role of acyl-coenzyme A:diacylglycerol acyltransferase 2 (DGAT2) in glucose and lipid… (More)
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Highly Cited
2004
Highly Cited
2004
Lipopenia and skin barrier abnormalities in DGAT2-deficient mice.
The synthesis of triglycerides is catalyzed by two known acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes. Although they… (More)
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2002
2002
Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin.
Glucose and insulin are anabolic signals which upregulate the transcriptions of a series of lipogenic enzymes to convert excess… (More)
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Highly Cited
2001
Highly Cited
2001
Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members.
Studies involving the cloning and disruption of the gene for acyl-CoA:diacylglycerol acyltransferase (DGAT) have shown that… (More)
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Highly Cited
2001
Highly Cited
2001
DGAT2 is a new diacylglycerol acyltransferase gene family: purification, cloning, and expression in insect cells of two polypeptides from Mortierella ramanniana with diacylglycerol acyltransferase…
Acyl CoA:diacylgycerol acyltransferase (EC; DGAT) catalyzes the final step in the production of triacylglycerol. Two polypeptides… (More)
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