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DERL3 gene

Known as: derlin-3, DERL3, DER1-LIKE DOMAIN FAMILY, MEMBER 3 
National Institutes of Health

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DERL1 gene

Papers overview

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2020
2020
DERL3 suppresses colorectal cancer metastasis through negatively regulating MYCN level.
BACKGROUND To illustrate the role of DERL3 in regulating the development of Colorectal cancer (CRC) and the underlying molecular… 
2020
2020
Biomechanically reduced expression of Derlin-3 is linked to the apoptosis of chondrocytes in the mandibular condylar cartilage via the endoplasmic reticulum stress pathway.
2019
2019
DERL3 functions as a tumor suppressor in gastric cancer
Highly Cited
2017
Highly Cited
2017
Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer
2017
2017
Overexpression of Derlin 3 is associated with malignant phenotype of breast cancer cells.
Breast cancer (BC) is the most common malignant tumor among women worldwide. Development of novel molecular targets is important… 
2016
2016
Abstract 2770: DERL3 hypermethylation alters rhabdomyosarcoma cell metabolism
Physiological cellular activity requires a precise control of the proteome. However, cancer cells have a distorted protein… 
Highly Cited
2014
Highly Cited
2014
A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect
Cancer cells possess aberrant proteomes that can arise by the disruption of genes involved in physiological protein degradation… 
Highly Cited
2010
Highly Cited
2010
Roles for Endoplasmic Reticulum–Associated Degradation and the Novel Endoplasmic Reticulum Stress Response Gene Derlin-3 in the Ischemic Heart
Rationale: Stresses, such as ischemia, impair folding of nascent proteins in the rough endoplasmic reticulum (ER), activating the… 
2007
2007
Mechanisms involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol
Ricin is a plant toxin produced in the seeds of the castor oil plant Ricinus communis. After endocytosis, the toxin is… 
2001
2001
A novel putative transmembrane protein, IZP6, is expressed in neural cells during embryogenesis
Gene trapping in mouse embryonic stem cells is an efficient method for identifying new genes and examining their functions. This… 
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