Skip to search formSkip to main contentSkip to account menu

DEFB4B gene

Known as: beta defensin 2, beta defensin-2, defensin beta 4B 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Human β-Defensin 2 and 3 and Their Mouse Orthologs Induce Chemotaxis through Interaction with CCR2
β-defensins play a dual role during immune response. Their direct antimicrobial properties contribute to the local innate immune… 
Highly Cited
2009
Highly Cited
2009
Farnesol promotes epithelial cell defense against Candida albicans through Toll-like receptor 2 expression, interleukin-6 and human beta-defensin 2 production.
Highly Cited
2008
Highly Cited
2008
Probiotic lactobacilli and VSL#3 induce enterocyte β‐defensin 2
Recent evidence suggests that probiotic bacteria may stabilize gut barrier function via induction of anti‐microbial peptides such… 
Highly Cited
2007
Highly Cited
2007
Induction of Human β-Defensin 2 by the Probiotic Escherichia coli Nissle 1917 Is Mediated through Flagellin
ABSTRACT Human β-defensin 2 (hBD-2) is an inducible antimicrobial peptide synthesized by the epithelium to counteract bacterial… 
Highly Cited
2004
Highly Cited
2004
NF-κB- and AP-1-Mediated Induction of Human Beta Defensin-2 in Intestinal Epithelial Cells by Escherichia coli Nissle 1917: a Novel Effect of a Probiotic Bacterium
ABSTRACT Little is known about the defensive mechanisms induced in epithelial cells by pathogenic versus probiotic bacteria. The… 
Highly Cited
2004
Highly Cited
2004
Identification and quantification of innate immune system mediators in human breast milk.
Breast-feeding decreases the risk of breast cancer in mothers and infection, allergy, and autoimmunity in infants. The presence… 
Highly Cited
2002
Highly Cited
2002
A model for antimicrobial gene therapy: demonstration of human beta-defensin 2 antimicrobial activities in vivo.
We transfected host cells with an antimicrobial peptide/protein-encoding gene as a way to enhance host defense mechanisms against… 
Highly Cited
2001
Highly Cited
2001
Mediators of Innate Immunity That Target Immature, But Not Mature, Dendritic Cells Induce Antitumor Immunity When Genetically Fused with Nonimmunogenic Tumor Antigens
Chemokine receptors are differentially expressed on immature and mature dendritic cells (DC). Herein, we demonstrate for the… 
Highly Cited
2001
Highly Cited
2001
Human beta defensin-1 and -2 expression in human pilosebaceous units: upregulation in acne vulgaris lesions.
A rich residential microflora is harboured by the distal outer root sheath of the hair follicle and the hair canal - normally… 
Highly Cited
1999
Highly Cited
1999
Mouse β-Defensin 3 Is an Inducible Antimicrobial Peptide Expressed in the Epithelia of Multiple Organs
ABSTRACT One component of host defense at mucosal surfaces is epithelium-derived peptides with antimicrobial activity called… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)