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Activation of Helicobacter pylori VacA Toxin by Alkaline or Acid Conditions Increases Its Binding to a 250-kDa Receptor Protein-tyrosine Phosphatase β*
Helicobacter pylori, a Gram-negative gastric bacterium, secretes VacA, a cytotoxin that causes vacuolar degeneration of susceptible cells. Velocity sedimentation analysis showed that treatment ofExpand
Protein-tyrosine phosphatase alpha, RPTP alpha, is a Helicobacter pylori VacA receptor.
Helicobacter pylori vacuolating cytotoxin, VacA, induces vacuolation, mitochondrial damage, cytochrome c release, and apoptosis of gastric epithelial cells. To detect gastric proteins that serve asExpand
Salmonella enteritidis FliC (Flagella Filament Protein) Induces Human β-Defensin-2 mRNA Production by Caco-2 Cells*
Antimicrobial peptides are crucial for host defense at mucosal surfaces. Bacterial factors responsible for induction of human β-defensin-2 (hBD-2) mRNA expression in Caco-2 human carcinoma cells wereExpand
Binding of Cationic α-Helical Peptides to Plasmid DNA and Their Gene Transfer Abilities into Cells*
Polycationic reagents such as cationic lipids and poly-l-lysine are widely used for gene transfer into cells in vitro and show promise as vectors for in vivo gene therapy applications as nonviralExpand
Characters of dendritic poly(L-lysine) analogues with the terminal lysines replaced with arginines and histidines as gene carriers in vitro.
The development of a non-viral gene delivery system into cells is an important key to realize the safe delivery of therapeutic genes without the side effects often pointed out for viral vectors. WeExpand
Vacuolating cytotoxin purified from Helicobacter pylori causes mitochondrial damage in human gastric cells.
We investigated the effects of vacuolating cytotoxin (VacA) prepared from Helicobacter pylori on the metabolism of gastric epithelial cells, AZ-521. VacA caused the ATP levels to decrease in aExpand
Morphologic Differentiation of HL-60 Cells Is Associated with Appearance of RPTPβ and Induction of Helicobacter pyloriVacA Sensitivity*
Phorbol 12-myristate 13-acetate (PMA) induces differentiation of human leukemic HL-60 cells into cells with macrophage-like characteristics and enhances the susceptibility of HL-60 cells to theExpand
Importance of hydrophobic region in amphiphilic structures of alpha-helical peptides for their gene transfer-ability into cells.
It has been showned that cationic alpha-helical peptides can be useful as nucleic acid-carrier molecules for gene transfer into cells. In order to investigate the significancemake sure of importanceExpand
Protein-tyrosine Phosphatase α, RPTPα, Is a Helicobacter pylori VacA Receptor*
Helicobacter pylori vacuolating cytotoxin, VacA, induces vacuolation, mitochondrial damage, cytochrome c release, and apoptosis of gastric epithelial cells. To detect gastric proteins that serve asExpand
Interaction of pleurocidin and its analogs with phospholipid membrane and their antibacterial activity.
A 25-mer cationic peptide pleurocidin, isolated from the winter flounder, has broad antibacterial activity. To clarify the structure-activity relationship, its properties and biological activity wereExpand
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