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DCC-2036

National Institutes of Health

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QuinolinesRebastinib Tosylate

Papers overview

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2019
2019
An open label, multicenter, phase 1b/2 study of rebastinib (DCC-2036) in combination with carboplatin to assess safety, tolerability, and pharmacokinetics in patients with advanced or metastatic…
TPS2666 Background: Rebastinib is a potent, orally administered, kinase switch control inhibitor selectively targeting the tunica… 
2013
2013
Kinase Inhibitor Therapy in CML: It's What's Inside That Counts
The paradigm-shifting clinical success of imatinib in the treatment of chronic myeloid leukemia (CML) established continuous… 
2012
2012
Overcoming Gleevec-resistance by blocking oncogene addiction in malignant hematologic cells
In some types of tumors, malignant cells are highly dependent on the constitutive activation of a certain protein encoded by… 
2012
2012
Non-tyrosine kinase inhibitor-targeting of BCR–ABL expressing cells
Th e introduction in clinical practice of tyrosine kinase inhibitors (TKIs) targeting the oncogenic BCR – ABL protein has had a… 
2012
2012
Ariad Pharmaceutical's ninja cancer drug inhibits armies of mutants.
Review
2011
Review
2011
Tyrosine kinase inhibitor therapy for chronic myeloid leukemia: approach to patients with treatment-naive or refractory chronic-phase disease.
The 21st century ushered in the dawn of a new era of targeted therapeutics and a dramatic shift in the management of chronic… 
2011
2011
A Phase 1 Study of DCC-2036, a Novel Oral Inhibitor of BCR-ABL Kinase, in Patients with Philadelphia Chromosome Positive (Ph+) Leukemias Including Patients with T315I Mutation
Abstract 601 Background. DCC-2036 is a novel and potent tyrosine kinase inhibitor (TKI) which binds to a novel region called the… 
2010
2010
A New BCR-ABL1 Mutation (L248R) Is Highly Resistant to Imatinib, Bosutinib, Nilotinib and Dasatinib, but Can Be Inhibited by AP-24534 and DCC-2036
Abstract 3398 Chronic Myeloid Leukemia (CML) treatment was radically modified by the discovery of imatinib (IM), a selective… 
Review
2010
Review
2010
Characteristics and Outcome of Chronic Myeloid Leukemia (CML) Patients with E255K and E255V BCR-ABL Kinase Domain Mutations.
Abstract 1226 Background: Mutations in the kinase domain (KD) of Abl represent the most common mechanism of resistance to… 
2007
2007
DCC-2036: A Novel Switch Pocket Inhibitor of ABL Tyrosine Kinase with Therapeutic Efficacy Against BCR-ABL T315I In Vitro and in a CML Mouse Model.
Therapy with ATP-competitive ABL kinase inhibitors, including imatinib (Gleevec), dasatinib (Sprycel), and nilotinib (Tasigna… 
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