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DAOCS activity

Known as: deacetoxycephalosporin C synthetase activity, deacetoxycephalosporin-C synthase activity, penicillin-N,2-oxoglutarate:oxygen oxidoreductase (ring-expanding) 
Catalysis of the reaction: 2-oxoglutarate + O(2) + penicillin N = CO(2) + deacetoxycephalosporin C + H(2)O + succinate. [EC:1.14.20.1, RHEA:20751]
National Institutes of Health

Papers overview

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2018
2018
Contraction of Universe with Speed C
Distances are the result of sensory perception. Physics is based on images created by us through observation and transmitted for… 
2007
2007
Relevant Double Mutations in Bioengineered Streptomyces clavuligerus Deacetoxycephalosporin C Synthase Result in Higher Binding Specificities Which Improve Penicillin Bioconversion
ABSTRACT Streptomyces clavuligerus deacetoxycephalosporin C synthase (ScDAOCS) is an important industrial enzyme for the… 
2005
2005
Directed Evolution of Streptomyces clavuligerus Deacetoxycephalosporin C Synthase for Enhancement of Penicillin G Expansion
ABSTRACT The deacetoxycephalosporin C synthase from Streptomyces clavuligerus was directly modified for enhancement of penicillin… 
2001
2001
Effect of solvents on bioconversion of penicillin G to deacetoxycephalosporin G.
The bioconversion of penicillin G, an inexpensive substrate, to the valuable intermediate for semisynthetic cephalosporin… 
1990
1990
Cloning and expression of a hybrid Streptomyces clavuligerus cefE gene in Penicillium chrysogenum
SummaryA hybrid cefE gene was constructed by juxtaposing promoter sequences from the Penicillium chrysogenum pcbC gene to the… 
1989
1989
Carbon source regulation of ACV synthetase inCephalosporium acremonium C-10
The high cephalosporin-producing strainCephalosporium acremonium C-10 was found to be still subject to carbon source regulation… 
Highly Cited
1986
Highly Cited
1986
Glucose regulation of cephamycin biosynthesis in Streptomyces lactamdurans is exerted on the formation of alpha-aminoadipyl-cysteinyl-valine and deacetoxycephalosporin C synthase.
Glucose exerted a concentration-dependent negative regulation on the biosynthesis of cephamycin C by Streptomyces lactamdurans… 
1981
1981
Microbiological ring expansion of penicillin N.
A mutant of Cephalosporium acremonium producing high amounts of penicillin N was isolated. This antibiotic was purified and… 
1974
1974
Synthesis of Deactoxycephalosporin C by a Mutant of Cephalosporium acremonium
A number of Cephalosporium acremonium mutants blocked in the synthesis of cephalosporin C were investigated for accumulation of… 
1974
1974
Letter: The occurrence of deacetoxycephalosporin C in fungi and streptomycetes.
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