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DA 1131

Known as: DA-1131 
National Institutes of Health

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Carbapenems

Papers overview

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2002
2002
Stability of New Carbapenem DA-1131 to Renal Dipeptidase (Dehydropeptidase I)
ABSTRACT The stability of DA-1131 to renal dipeptidase (RDPase) (EC 3.4.13.19) was compared with that of imipenem and meropenem… 
1999
1999
Pharmacokinetic changes of a new carbapenem, DA-1131, after intravenous administration to spontaneously hypertensive rats and deoxycorticosterone acetate-salt-induced hypertensive rats.
The pharmacokinetics of a new carbapenem, DA-1131, were compared after i.v. administration of the drug, 50 mg/kg, to… 
1999
1999
Effect of Probenecid on the Renal Excretion Mechanism of a New Carbapenem, DA-1131, in Rats and Rabbits
ABSTRACT The effects of probenecid, an anion transport inhibitor, on the renal excretion mechanism of a new anionic carbapenem… 
1999
1999
Nephroprotective effect of betamipron on a new carbapenem, DA‐1131, in rabbits
The nephroprotective effect of betamipron (200 mg/kg) was evaluated after intravenous administration of a high dose of DA‐1131… 
1998
1998
Pharmacokinetics and tissue distribution of a new carbapenem, DA‐1131, after intravenous administration to mice, rats, rabbits and dogs
The pharmacokinetic parameters including tissue distribution and/or biliary excretion of DA‐1131, a new carbapenem, were… 
1998
1998
Pharmacokinetics of a New Carbapenem, DA-1131, after Intravenous Administration to Rats with Uranyl Nitrate-Induced Acute Renal Failure
ABSTRACT Because the physiological changes that occur in patients with acute renal failure could alter the pharmacokinetics of… 
1998
1998
Interspecies pharmacokinetic scaling of a new carbapenem, DA‐1131, in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics
The total body clearance (Cl), renal clearance (Clr), and apparent volume of distribution at steady state (Vss) of DA‐1131, a new… 
1998
1998
Pharmacokinetics of a new carbapenem, DA‐1131, after intravenous administration to rats with alloxan‐induced diabetes mellitus
Because physiological changes occurring in diabetes patients could alter the pharmacokinetics of drugs used to treat the disease… 
1998
1998
No effect of probenecid on the renal excretion mechanism of a new carbapenem, DA-1131, in dogs.
The effect of probenecid, an anion transport inhibitor, on the renal excretion mechanism of a new anionic carbapenem, DA-1131… 
1995
1995
Stability, tissue metabolism, tissue distribution, and blood partition of DA-1131, a new carbapenem.
The stability of DA-1131 after incubation in various pH solutions, human plasma, human urine, human gastric juice, rat liver… 
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