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Cytosine deaminase

Known as: Deaminase, Cytosine, Aminohydrolase, Cytosine, Cytosine Aminohydrolase 
An enzyme which catalyzes the deamination of CYTOSINE resulting in the formation of URACIL. It can also act on 5-methylcytosine to form THYMIDINE.
National Institutes of Health

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Narrower (3)

APOBEC3F protein, humanFcy-hEGF fusion proteincodA protein, E coli
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Papers overview

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Highly Cited
2016
Highly Cited
2016
The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis
Cytosine mutations within TCA/T motifs are common in cancer. A likely cause is the DNA cytosine deaminase APOBEC3B (A3B). However… 
Highly Cited
2016
Highly Cited
2016
The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer
An antiviral enzyme promotes drug resistance in breast cancer. Breast tumors often display extreme genetic heterogeneity… 
Highly Cited
2013
Highly Cited
2013
Endogenous APOBEC3A DNA Cytosine Deaminase Is Cytoplasmic and Nongenotoxic*
Background: APOBEC3A is a potentially genotoxic DNA cytosine deaminase expressed in myeloid lineage cells. Results: Exogenous… 
Highly Cited
2008
Highly Cited
2008
Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice
Previously, we validated capability of human adipose tissue‐derived mesenchymal stem cells (AT‐MSC) to serve as cellular vehicles… 
Highly Cited
2005
Highly Cited
2005
The Retroviral Hypermutation Specificity of APOBEC3F and APOBEC3G Is Governed by the C-terminal DNA Cytosine Deaminase Domain*
The human proteins APOBEC3F and APOBEC3G restrict retroviral infection by deaminating cytosine residues in the first cDNA strand… 
Review
1999
Review
1999
Assays for noninvasive imaging of reporter gene expression.
Highly Cited
1997
Highly Cited
1997
In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene.
The alpha-fetoprotein (AFP) gene is normally expressed in fetal liver and is transcriptionally silent in adult liver but… 
Highly Cited
1994
Highly Cited
1994
Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells…
The gene encoding cytosine deaminase (CD) has been expressed in the human colorectal carcinoma cell line WiDr. Metabolism studies… 
Highly Cited
1994
Highly Cited
1994
Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor.
Successful expression of the cytosine deaminase (CD) suicide gene in vivo is demonstrated in three weakly immunogenic murine… 
Highly Cited
1993
Highly Cited
1993
In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase.
A human colorectal carcinoma cell line, WiDr, was genetically engineered to express the nonmammalian enzyme, cytosine deaminase… 
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