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Cytidine Deaminase Inhibitor

Any substance that inhibits cytidine deaminase, an enzyme that scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
A Phase 2 Dose-Confirmation Study of Oral ASTX727, a Combination of Oral Decitabine with a Cytidine Deaminase Inhibitor (CDAi) Cedazuridine (E7727), in Subjects with Myelodysplastic Syndromes (MDS)
Poster can be downloaded from www.astx.com ASTX727-PB17(701) Abstract # 4274 Guillermo Garcia-Manero 1, Elizabeth A. Griffiths2… 
2008
2008
Optimized blood sampling with cytidine deaminase inhibitor for improved analysis of capecitabine metabolites.
2007
2007
Quantitative determination of the cytidine deaminase inhibitor tetrahydrouridine (THU) in mouse plasma by liquid chromatography/electrospray ionization tandem mass spectrometry.
A number of anticancer drugs are cytidine analogues that undergo metabolic deactivation catalyzed by cytidine deaminase (CD). 3,4… 
2002
2002
Analytical and pharmacokinetic studies with 5-chloro-2'-deoxycytidine.
1998
1998
Accumulation of arabinosyluracil 5'-triphosphate during arabinosylcytosine therapy in circulating blasts of patients with acute myelogenous leukemia.
Arabinosylcytosine (ara-C) is the most effective nucleoside analogue for treatment of acute myelogenous leukemia. The… 
1995
1995
Characterization of a multidrug resistant human erythroleukemia cell line (K562) exhibiting spontaneous resistance to 1-beta-D-arabinofuranosylcytosine.
We have assessed the response of a previously characterized multidrug resistant (MDR) human erythroleukemia cell line (K562R) to… 
1989
1989
Selective radiosensitization and cytotoxicity of human melanoma cells using halogenated deoxycytidines and tetrahydrouridine.
1986
1986
Deoxycytidine stimulates the in vitro growth of normal CFU-GM and reverses the negative regulatory effects of acidic isoferritin and prostaglandin E1.
We have examined the effect of supraphysiologic concentrations of the naturally occurring nucleoside deoxycytidine (dCyd) on the… 
Review
1978
Review
1978
ARA-C analogs.
Ara-C, a phase-specific antitumor agent, is rapidly deactivated by the enzyme cytidine deaminase. A prolongation of the… 
1975
1975
Deoxycytidine transport in the presence of a cytidine deaminase inhibitor and the transport of uracil in Escherichia coli B.
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