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Cystine/Glutamate Transporter Protein

Known as: System Xc(-) Transporter-Related Protein, Amino Acid Transport System xc-, XCT 
Cystine/glutamate transporter protein (501aa, ~55 kDa) is encoded by the human SLC7A11 gene. This protein is involved in the exchange of anionic… 
National Institutes of Health

Related topics

Related topics

14 relations
Amino Acid TransporterCellular MembraneIntegral Membrane ProteinsIntracellular Transport

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Alcohol and DNA Methylation: An Epigenome-Wide Association Study in Blood and Normal Breast Tissue.
The biological mechanisms driving associations between alcohol consumption and chronic diseases might include epigenetic… 
2017
2017
Role of uL3 in Multidrug Resistance in p53-Mutated Lung Cancer Cells
Cancer is one of the most common causes of death among adults. Chemotherapy is crucial in determining patient survival and… 
Highly Cited
2015
Highly Cited
2015
Cystathionine Is a Novel Substrate of Cystine/Glutamate Transporter
Background: System xc− is involved in various pathophysiological conditions, such as neurodegenerative disorders and cancer… 
Highly Cited
2014
Highly Cited
2014
Transcription Factor Nrf1 Negatively Regulates the Cystine/Glutamate Transporter and Lipid-Metabolizing Enzymes
ABSTRACT Liver-specific Nrf1 (NF-E2-p45-related factor 1) knockout mice develop nonalcoholic steatohepatitis. To identify… 
Review
2011
Review
2011
Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: a role for mitochondria and the nuclear factor-E2-related factor 2-Kelch-like ECH-associated protein 1…
Type 2 diabetes is an age-related disease associated with vascular pathologies, including severe blindness, renal failure… 
Review
2010
Review
2010
xCT modulation in gliomas: relevance to energy metabolism and tumor microenvironment normalization.
Highly Cited
2007
Highly Cited
2007
Induction of cystine/glutamate transporter in bacterial lipopolysaccharide induced endotoxemia in mice
BackgroundCystine/glutamate transporter, system xc-, contributes to the maintenance of intracellular glutathione levels and the… 
Highly Cited
2007
Highly Cited
2007
Expression and function of cystine/glutamate transporter in neutrophils
Reactive oxygen species (ROS) produced by neutrophils are essential in the host defense against infections but may be harmful to… 
Highly Cited
2001
Highly Cited
2001
Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells.
PURPOSE The purpose of this investigation was to provide evidence for the expression of the cystine/glutamate transporter (x(c… 
Highly Cited
2000
Highly Cited
2000
Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc-.
Transport of system xc- is an exchange agency with high specificity for anionic form of cystine and glutamate. The protein… 
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