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Cyclic AMP-Dependent Protein Kinase Type I

Known as: Cyclic AMP-Dependent Protein Kinase Type I [Chemical/Ingredient], Cyclic AMP Dependent Protein Kinase Type 1, Protein Kinase Type I, Cyclic AMP Dependent 
A cyclic AMP-dependent protein kinase subtype primarily found in the CYTOPLASM. They are tetrameric proteins that contain two catalytic subunits and… Expand
National Institutes of Health

Related topics

Related topics

7 relations
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Regulation of arginase‐1 expression in macrophages by a protein kinase a type I and histone deacetylase dependent pathway
The aim of the current study was to investigate the cAMP‐dependent regulation of arginase‐1 (ARG1) expression in RAW‐macrophages… Expand
2004
2004
Effect of activated platelets on expression of cytokines in peripheral blood mononuclear cells - potential role of prostaglandin E2.
Platelets may act as inflammatory cells. To study the effects of soluble and cell-bound platelet factors on the expression of… Expand
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Highly Cited
2003
Highly Cited
2003
Impaired Secretion of IL-10 by T Cells from Patients with Common Variable Immunodeficiency–Involvement of Protein Kinase A Type I1
Common variable immunodeficiency (CVID) is a heterogeneous group of B cell deficiency syndromes. T cell abnormalities are present… Expand
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2001
2001
Oral administration of a novel taxane, an antisense oligonucleotide targeting protein kinase A, and the epidermal growth factor receptor inhibitor Iressa causes cooperative antitumor and…
PURPOSE Protein kinase A type I (PKAI) and the epidermal growth factor receptor (EGFR) play a role in neoplastic transformation… Expand
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2001
2001
Combined blockade of protein kinase A and bcl-2 by antisense strategy induces apoptosis and inhibits tumor growth and angiogenesis.
Protein kinase A type I (PKAI) plays a key role in neoplastic transformation, conveys mitogenic signals from different sources… Expand
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Highly Cited
2000
Highly Cited
2000
Antitumor activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense…
Recent studies have suggested that selective inhibition of mitogenic pathways may improve the antitumor activity of ionizing… Expand
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Highly Cited
2000
Highly Cited
2000
Oral antisense that targets protein kinase A cooperates with taxol and inhibits tumor growth, angiogenesis, and growth factor production.
Protein kinase A type I (PKAI) transduces mitogenic signals from different growth factors and oncogenes and is overexpressed in… Expand
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2000
2000
PKAI as a potential target for therapeutic intervention.
We have mapped a molecular mechanism for the impaired T-cell function in HIV infection and common variable immunodeficiency (CVI… Expand
Highly Cited
1999
Highly Cited
1999
Increased activation of protein kinase A type I contributes to the T cell deficiency in common variable immunodeficiency.
The molecular mechanisms underlying the T cell dysfunction often present in common variable immunodeficiency (CVI) are not… Expand
1996
1996
8-chloro-cAMP enhances the growth inhibitory effect of cytotoxic drugs in human colon cancer cells.
8-Cl-cAMP is a novel agent able to inhibit the growth of a wide variety of cancer cell types in vitro and in vivo by interfering… Expand
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