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Cyclic AMP-Dependent Protein Kinase Type I

Known as: Cyclic AMP-Dependent Protein Kinase Type I [Chemical/Ingredient], Cyclic AMP Dependent Protein Kinase Type 1, Protein Kinase Type I, Cyclic AMP Dependent 
A cyclic AMP-dependent protein kinase subtype primarily found in the CYTOPLASM. They are tetrameric proteins that contain two catalytic subunits and… Expand
National Institutes of Health

Related topics

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7 relations
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects
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Papers overview

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2008
2008
Regulation of arginase-1 expression in macrophages by a protein kinase A type I and histone deacetylase dependent pathway.
The aim of the current study was to investigate the cAMP-dependent regulation of arginase-1 (ARG1) expression in RAW-macrophages… Expand
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2004
2004
Effect of activated platelets on expression of cytokines in peripheral blood mononuclear cells - potential role of prostaglandin E2.
Platelets may act as inflammatory cells. To study the effects of soluble and cell-bound platelet factors on the expression of… Expand
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2003
2003
Impaired secretion of IL-10 by T cells from patients with common variable immunodeficiency--involvement of protein kinase A type I.
Common variable immunodeficiency (CVID) is a heterogeneous group of B cell deficiency syndromes. T cell abnormalities are present… Expand
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2001
2001
Oral administration of a novel taxane, an antisense oligonucleotide targeting protein kinase A, and the epidermal growth factor receptor inhibitor Iressa causes cooperative antitumor and…
PURPOSE Protein kinase A type I (PKAI) and the epidermal growth factor receptor (EGFR) play a role in neoplastic transformation… Expand
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2001
2001
Combined blockade of protein kinase A and bcl-2 by antisense strategy induces apoptosis and inhibits tumor growth and angiogenesis.
Protein kinase A type I (PKAI) plays a key role in neoplastic transformation, conveys mitogenic signals from different sources… Expand
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2000
2000
Antitumor activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense…
Recent studies have suggested that selective inhibition of mitogenic pathways may improve the antitumor activity of ionizing… Expand
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2000
2000
Oral antisense that targets protein kinase A cooperates with taxol and inhibits tumor growth, angiogenesis, and growth factor production.
Protein kinase A type I (PKAI) transduces mitogenic signals from different growth factors and oncogenes and is overexpressed in… Expand
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2000
2000
PKAI as a potential target for therapeutic intervention.
We have mapped a molecular mechanism for the impaired T-cell function in HIV infection and common variable immunodeficiency (CVI… Expand
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1999
1999
Increased activation of protein kinase A type I contributes to the T cell deficiency in common variable immunodeficiency.
The molecular mechanisms underlying the T cell dysfunction often present in common variable immunodeficiency (CVI) are not… Expand
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1996
1996
8-chloro-cAMP enhances the growth inhibitory effect of cytotoxic drugs in human colon cancer cells.
8-Cl-cAMP is a novel agent able to inhibit the growth of a wide variety of cancer cell types in vitro and in vivo by interfering… Expand
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