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Crixivan

 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

IndinavirIndinavir Sulfate
Indinavir 200 MG Oral Capsule [Crixivan]Indinavir Oral Capsule [Crixivan]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
A highly efficient tandem [3 + 2] “click” cycloaddition/6-exo-cyclization strategy for the construction of triazole fused pyrazines
The pharmaceutically important tetrahydro-[1,2,3]triazolopyrazine heterocyclic architecture has been synthesized via a concise… Expand
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Review
2005
Review
2005
Schizophrenia and comorbid human immunodeficiency virus or hepatitis C virus.
Patients with schizophrenia are at significantly increased risk for infection with human immunodeficiency virus (HIV), hepatitis… Expand
2002
2002
CRIXIVAN ® ( INDINAVIR SULFATE ) CAPSULES
  • 2002
    • Corpus ID: 53004650
DESCRIPTION CRIXIVAN (indinavir sulfate) is an inhibitor of the human immunodeficiency virus (HIV) protease. CRIXIVAN Capsules… Expand
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2001
2001
Synthesis of nucleoside analogs and new Tat protein inhibitors
Two studies, concerning the synthesis of original nucleoside analogs regarded as an application of heterochemistry on… Expand
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2000
2000
Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors.
Recent results from human clinical trials have established the critical role of HIV protease inhibitors in the treatment of… Expand
Highly Cited
1999
Highly Cited
1999
Microbial conversion of indene to indandiol: a key intermediate in the synthesis of CRIXIVAN.
Indene is oxidized to mixtures of cis- and trans-indandiols and related metabolites by Pseudomonas putida and Rhodococcus sp… Expand
Review
1999
Review
1999
North-South research partnerships: the ethics of carrying out research in developing countries
The new phase of North-South research collaboration was caught in a snapshot published recently in a popular weekly newsmagazine… Expand
Review
1998
Review
1998
The integration of medicinal chemistry, drug metabolism, and pharmaceutical research and development in drug discovery and development. The story of Crixivan, an HIV protease inhibitor.
History tells us that when given a reasonably active lead compound, medicinal chemists usually are able to increase the potency… Expand
Highly Cited
1996
Highly Cited
1996
Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor.
Indinavir (IDV) (also called CRIXIVAN, MK-639, or L-735,524) is a potent and selective inhibitor of the human immunodeficiency… Expand
1996
1996
Clinical update: impact of HIV protease inhibitors on the treatment of HIV-infected tuberculosis patients with rifampin.
  • MMWR. Morbidity and mortality weekly report
  • 1996
    • Corpus ID: 25134566
In 1995 and 1996, the Food and Drug Administration (FDA) approved three products in the new protease inhibitor class of drugs… Expand
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