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Copper Cu 64-ATSM

Known as: (64)Cu-ATSM, Copper-64-diacetyl-bis(N4-methylthiosemicarbazone) 
A radioconjugate consisting of a lipophilic copper(II)bis(thiosemicarbazone) labeled with the positron- and beta-emitting isotope (64)Cu with hypoxia… 
National Institutes of Health

Papers overview

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Review
2020
Review
2020
Hypoxia PET imaging beyond 18F-FMISO in patients with high-grade glioma: 18F-FAZA and other hypoxia radiotracers
High-grade gliomas are aggressive primitive brain tumors presenting aberrant vasculature, regional necrosis, and areas of hypoxia… 
2014
2014
Comparison of intratumoral FDG and Cu-ATSM distributions in cancer tissue originated spheroid (CTOS) xenografts, a tumor model retaining the original tumor properties.
2013
2013
Comparison of 18F-Fluoroazomycin-Arabinofuranoside and 64Cu-Diacetyl-Bis(N4-Methylthiosemicarbazone) in Preclinical Models of Cancer
Hypoxic regions are present in different types of cancer and are a negative prognostic factor for disease progression and… 
2012
2012
Copper-64-diacetyl-bis(N(4)-methylthiosemicarbazone) pharmacokinetics in FaDu xenograft tumors and correlation with microscopic markers of hypoxia.
2012
2012
Multimodality functional imaging of spontaneous canine tumors using 64Cu-ATSM and 18FDG PET/CT and dynamic contrast enhanced perfusion CT.
2010
2010
Nitroimidazole conjugates of bis(thiosemicarbazonato)64Cu(II) - Potential combination agents for the PET imaging of hypoxia.
2010
2010
Simulation of tissue activity curves of 64Cu-ATSM for sub-target volume delineation in radiotherapy
There is much interest in positron emission tomography (PET) for measurements of regional tracer concentration in hypoxic tumour… 
2009
2009
Elucidation of the human serum albumin (HSA) binding site for the Cu-PTSM and Cu-ATSM radiopharmaceuticals.
The Cu-PTSM (pyruvaldehyde bis(N(4)-methylthiosemicarbazonato)copper(II)) and Cu-ATSM (diacetyl bis(N(4… 
Review
2009
Review
2009
Positron Emission Tomography Imaging of Hypoxia.
Hypoxia imaging has applications in functional recovery in ischemic events such as stroke and myocardial ischemia, but especially… 
2008
2008
60Cu-ATSM in Cancer of the Uterine Cervix
Tumor uptake of copper(II)-diacetyl-bis(N4-methylthiosemicarbazone) (copper-ATSM), a hypoxia-targeting radiopharmaceutical… 
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