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We compared the imaging characteristics and hypoxia selectivity of 4 hypoxia PET radiotracers (18F-fluoromisonidazole [18F-FMISO… Expand BACKGROUND AND PURPOSE: Hypoxic tissue evaluation in glioma is important for predicting treatment response and establishing… Expand Tumor uptake of copper(II)-diacetyl-bis(N4-methylthiosemicarbazone) (copper-ATSM), a hypoxia-targeting radiopharmaceutical… Expand UNLABELLED
Cu-Diacetyl-bis(N(4)-methylthiosemicarbazone) (Cu-ATSM) is a recently developed PET imaging agent for tumor hypoxia… Expand PURPOSE
To compare two potential positron emission tomography (PET) tracers of tumor hypoxia in an animal model.
METHODS AND… Expand We have used copper-64-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (64Cu–PTSM) to radiolabel cells ex vivo for in vivo positron… Expand Systemic administration of hypoxia-selective (64)Cu-diacetyl-bis(N(4)-methylthiosemicarbazone) ((64)Cu-ATSM) has increased… Expand Hypoxia in tumors has been related to poor response to conventional therapies. This paper will discuss the methods, both invasive… Expand Abstract62Cu labeled diacetyl-bis(N4-methylthiosemicarbazone) (62Cu-ATSM) has been proposed as a generator-produced, positron… Expand UNLABELLED
An ideal hypoxia imaging agent should have high membrane permeability for easy access to intracellular mitochondria… Expand