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The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.
PPARalpha is a critical regulator of myocardial fatty acid uptake and utilization, activation of cardiac PPARalpha regulatory pathways results in a reciprocal repression of glucose uptake and usage pathways, and derangements in myocardian energy metabolism typical of the diabetic heart can become maladaptive, leading to cardiomyopathy.
A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography
An in vivo method for use with positron emission tomography (PET) that results in a quantitative characterization of neuroleptic binding sites using radiolabeled spiperone, the first direct evidence that PET can be used to characterize quantitatively, locally and in vivo, drug binding sites in brain.
Metabolic flare: indicator of hormone responsiveness in advanced breast cancer.
The functional status of tumor ERs can be characterized in vivo by PET with FDG and FES, and the results of PET are predictive of responsiveness to tamoxifen therapy in patients with advanced ER(+) breast cancer.
11C-acetate PET imaging of prostate cancer: detection of recurrent disease at PSA relapse.
Preliminary data show that (11)C-acetate is a promising tracer for detection of recurrent prostate cancer and has higher sensitivity than (18)F-FDG PET.
Positron Emission Tomographic Measurement of Cerebral Blood Flow and Permeability—Surface Area Product of Water Using [15O]Water and [11C]Butanol
The use of [11C]butanol is validated as an alternative freely diffusible tracer for PET in humans to determine the underestimation of CBF that occurs with H215O and the effect of tissue heterogeneity and errors in flow measurement on the calculation of PSw.
Transgenic Expression of Fatty Acid Transport Protein 1 in the Heart Causes Lipotoxic Cardiomyopathy
In the absence of systemic metabolic disturbances, such as diabetes or hyperlipidemia, perturbation ofCardiomyocyte lipid homeostasis leads to cardiac dysfunction with pathophysiological findings similar to those in diabetic cardiomyopathy, and the MHC-FATP model supports a role for FATPs in FFA import into the heart in vivo.
Relationship between lipophilicity and brain extraction of C-11-labeled radiopharmaceuticals.
The brain extraction of fifteen C-11-labeled compounds during a single capillary transit was studied in adult baboons by external detection of these tracers after injection into the internal carotid artery, suggesting that a radiopharmaceutical designed to measure blood flow should have a log Poct value of between 0.9 and 2.5.
A novel approach to overcome hypoxic tumor resistance: Cu-ATSM-guided intensity-modulated radiation therapy.
  • K. Chao, W. Bosch, M. Welch
  • Medicine, Physics
    International journal of radiation oncology…
  • 15 March 2001
Preparation of four fluorine- 18-labeled estrogens and their selective uptakes in target tissues of immature rats.
Four fluorine- 18-labeled estrogens have high affinity for the estrogen receptor and are taken up by target tissues, such as the uterus, with very high selectivity in immature female rats.