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Conessine Hydrobromide

Known as: 3-beta-(Dimethylamino)con-5-enine Dihydrobromide, Conessin Dihydrobromide, Konessin Dihydrobromide 
National Institutes of Health

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conessine

Papers overview

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2013
2013
Stimulation of Sigma Receptors with Afobazole Blocks Activation of Microglia and Reduces Toxicity Caused by Amyloid-β25–35
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the leading cause of senile dementia in the United States… 
Highly Cited
2011
Highly Cited
2011
Decreases in Cocaine Self-Administration with Dual Inhibition of the Dopamine Transporter and σ Receptors
Sigma receptor (σR) antagonists attenuate many behavioral effects of cocaine but typically not its reinforcing effects in self… 
Highly Cited
2009
Highly Cited
2009
Mast Cells Down-Regulate CD4+CD25+ T Regulatory Cell Suppressor Function via Histamine H1 Receptor Interaction1
Mast cells promote both innate and acquired immune responses, but little is known about the effect of mast cells on T regulatory… 
Highly Cited
2009
Highly Cited
2009
Smoke, Choline Acetyltransferase, Muscarinic Receptors, and Fibroblast Proliferation in Chronic Obstructive Pulmonary Disease
Acetylcholine (ACh), synthesized by choline acetyltransferase (ChAT), and muscarinic M1, M2, and M3 receptors (MRs) are involved… 
Highly Cited
2009
Highly Cited
2009
H3 Histamine Receptor–Mediated Activation of Protein Kinase Cα Inhibits the Growth of Cholangiocarcinoma In vitro and In vivo
Histamine regulates functions via four receptors (HRH1, HRH2, HRH3, and HRH4). The d-myo-inositol 1,4,5-trisphosphate (IP3)/Ca2… 
Highly Cited
2007
Highly Cited
2007
H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway
Histamine regulates many functions by binding to four histamine G-coupled receptor proteins (H1R, H2R, H3R and H4R). As H3R… 
Highly Cited
2006
Highly Cited
2006
Intrathecal treatment with σ1 receptor antagonists reduces formalin‐induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice
1 Although previous reports have suggested that the sigma 1 (σ1) receptor may be involved in pain sensation, its specific site of… 
Highly Cited
2005
Highly Cited
2005
σ Receptor Activation Blocks Potassium Channels and Depresses Neuroexcitability in Rat Intracardiac Neurons
The σ receptors have been implicated in the regulation of the cardiovascular system, and σ-1 receptor transcripts have been found… 
Highly Cited
2005
Highly Cited
2005
Evaluation of Histamine H 1-, H 2-, and H 3-Receptor Ligands at the Human Histamine H 4 Receptor : Identification of 4-Methylhistamine as the First Potent and Selective H 4 Receptor Agonist
The histamine H4 receptor (H4R) is involved in the chemotaxis of leukocytes and mast cells to sites of inflammation and is… 
Review
1979
Review
1979
Interactions of hyperthermia and chemotherapy in animals.
  • J. Marmor
  • Cancer research
  • 1979
  • Corpus ID: 247746
In tissue culture, the cytotoxicity of a number of commonly used chemotherapeutic drugs is greatly enhanced at elevated… 
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