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Conessine Hydrobromide

Known as: 3-beta-(Dimethylamino)con-5-enine Dihydrobromide, Conessin Dihydrobromide, Konessin Dihydrobromide 
 
National Institutes of Health

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conessine

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2013
2013
Stimulation of sigma receptors with afobazole blocks activation of microglia and reduces toxicity caused by amyloid-β25-35.
Alzheimer's disease (AD) is a progressive neurodegenerative disease and the leading cause of senile dementia in the United States… Expand
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2011
2011
Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.
Sigma receptor (σR) antagonists attenuate many behavioral effects of cocaine but typically not its reinforcing effects in self… Expand
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2011
2011
A Role for Sigma Receptors in Stimulant Self Administration and Addiction
Sigma1 receptors (σ1Rs) represent a structurally unique class of intracellular proteins that function as chaperones. σ1Rs… Expand
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2009
2009
Smoke, choline acetyltransferase, muscarinic receptors, and fibroblast proliferation in chronic obstructive pulmonary disease.
Acetylcholine (ACh), synthesized by choline acetyltransferase (ChAT), and muscarinic M(1), M(2), and M(3) receptors (MRs) are… Expand
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2009
2009
Mast cells down-regulate CD4+CD25+ T regulatory cell suppressor function via histamine H1 receptor interaction.
Mast cells promote both innate and acquired immune responses, but little is known about the effect of mast cells on T regulatory… Expand
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2009
2009
H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo.
Histamine regulates functions via four receptors (HRH1, HRH2, HRH3, and HRH4). The d-myo-inositol 1,4,5-trisphosphate (IP(3))/Ca… Expand
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2007
2007
H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway
Histamine regulates many functions by binding to four histamine G-coupled receptor proteins (H1R, H2R, H3R and H4R). As H3R… Expand
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2007
2007
Stereoselective action of (+)-morphine over (-)-morphine in attenuating the (-)-morphine-produced antinociception via the naloxone-sensitive sigma receptor in the mouse.
We have previously demonstrated that (+)-morphine and (-)-morphine given spinally stereoselectively attenuate the spinally… Expand
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Highly Cited
2006
Highly Cited
2006
Intrathecal treatment with sigma1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice.
Although previous reports have suggested that the sigma 1 (sigma(1)) receptor may be involved in pain sensation, its specific… Expand
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2005
2005
Evaluation of Histamine H 1-, H 2-, and H 3-Receptor Ligands at the Human Histamine H 4 Receptor : Identification of 4-Methylhistamine as the First Potent and Selective H 4 Receptor Agonist
The histamine H4 receptor (H4R) is involved in the chemotaxis of leukocytes and mast cells to sites of inflammation and is… Expand
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