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Complex Karyotype

Karyotype with at least three chromosomal aberrations.
National Institutes of Health

Related topics

Related topics

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Cytogenetically Normal Acute Myeloid Leukemia

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Complex karyotype is a stronger predictor than del(17p) for an inferior outcome in relapsed or refractory chronic lymphocytic leukemia patients treated with ibrutinib‐based regimens
Ibrutinib is active in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL). In patients treated with… 
Highly Cited
2012
Highly Cited
2012
TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome.
To assess the frequency of TP53 alterations and their correlation with other genetic changes and outcome in acute myeloid… 
Highly Cited
2012
Highly Cited
2012
DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia
DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia 
Highly Cited
2009
Highly Cited
2009
TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis
TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor… 
Highly Cited
2008
Highly Cited
2008
Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype.
PURPOSE To investigate the prognostic value of various cytogenetic components of a complex karyotype in acute myeloid leukemia… 
Review
2008
Review
2008
Cytogenetic, molecular genetic, and clinical characteristics of acute myeloid leukemia with a complex karyotype.
  • K. Mrózek
  • Seminars in oncology
  • 2008
  • Corpus ID: 27179812
Patients with acute myeloid leukemia (AML) harboring three or more acquired chromosome aberrations in the absence of the… 
Review
2007
Review
2007
Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern…
Pretreatment cytogenetics is a known predictor of outcome in hematologic malignancies. However, its usefulness in adult acute… 
Highly Cited
2002
Highly Cited
2002
Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from…
We analyzed prospectively 1213 adults with de novo acute myeloid leukemia (AML) to ascertain the prognostic impact of cytogenetic… 
Highly Cited
2001
Highly Cited
2001
Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or…
PURPOSE To study mutations and loss of heterozygosity (LOH) of p53 in therapy-related myelodysplasia (t-MDS) and acute myeloid… 
Review
1990
Review
1990
Chromosome aberrations in B-cell chronic lymphocytic leukemia. Pathogenetic and clinical implications.
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